17623-72-2Relevant articles and documents
BENZAMIDE TRPA1 ANTAGONISTS
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Page/Page column 35, (2014/12/12)
Compounds of formula I, pharmaceutically acceptable salts thereof, diastereomers, enantiomers, or mixtures thereof: wherein R, X, Y, Z, n and A are as defined in the specification, as well as pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
Diastereochemical diversity of imidazoline scaffolds via substrate controlled TMSCI mediated cycloaddition of azlactones
Sharma, Vasudha,Tepe, Jetze J.
, p. 5091 - 5094 (2007/10/03)
(Chemical Equation Presented) We report herein a trimethylsilyl chloride mediated substrate controlled 1,3-dipolar cycloaddition for the diastereoselective synthesis of either syn- or anti-imidazolines. This method provides scaffolds with four points of diversity and control over two stereocenters.
Intramolecular Participation by a Neighboring Amide Group in the Hydrolysis of N-Acylimidazoles
Kogan, Robert L.,Fife, Thomas H.
, p. 5229 - 5232 (2007/10/02)
Rate constants have been determined for the disappearance of the N-acylimidazole derivatives of N-acetylphenylalanine and N-acetylvaline in H2O at 30 deg C.The pH-rate constant profiles are characterized by large pH-independent regions.These reactions are