17624-36-1

Basic information

• Product Name: 2-pyridyllithium
• Synonyms: 2-pyridyllithium;2-Lithiopyridine;Einecs 241-600-4
• CAS NO: 17624-36-1
• Molecular Formula: C₅H₄N*Li
• Molecular Weight: 85.03296
• EINECS: 241-600-4
• Mol File: 17624-36-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 115.3°Cat760mmHg
• Flash Point: 20°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 22.8mmHg at 25°C
• CAS DataBase Reference: 2-pyridyllithium(CAS DataBase Reference)
• NIST Chemistry Reference: 2-pyridyllithium(17624-36-1)
• EPA Substance Registry System: 2-pyridyllithium(17624-36-1)

Safety Data

• Hazardous Substances Data: 17624-36-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H4N.Li/c1-2-4-6-5-3-1;/h1-2,4-5H;/q-1;+1

Upstream product

• 109-04-6 2-bromo-pyridine 
• 109-72-8 n-butyllithium 

Downstream Products

• 19437-26-4 2,2'-dipyridyl ketone 
• 56970-92-4 pyridin-2-yl(pyridin-4-yl)methanone 
• 107776-02-3 1-(4-chlorophenyl)-1-(2-pyridyl)-1-propanol 
• 54467-34-4 phenylbis(pyridine-2-yl)methanol 
• 101273-89-6 [2]Furyl-phenyl-[2]pyridyl-methanol 
• 73569-80-9 tris(2-pyridyl)methyl alcohol 
• 107153-95-7 1-(4-chlorophenyl)-2-methyl-1-(2-pyridyl)-1-propanol 
• 103153-74-8 2-(1-phenyl-3-pyrrolidin-1-yl-propyl)-pyridine 
• 70708-25-7 1-phenyl-1-[2]pyridyl-3-pyrrolidino-propan-1-ol 
• 102008-18-4 2-(1-phenyl-3-piperidino-propyl)-pyridine 
• 64436-62-0 9-(pyridin-2-yl)-9H-fluoren-9-ol 
• 70708-26-8 1-[2]pyridyl-3-pyrrolidino-1-o-tolyl-propan-1-ol 
• 114254-86-3 2-[1-(4-chloro-phenyl)-3-pyrrolidin-1-yl-propyl]-pyridine 
• 102167-02-2 1-(4-ethyl-phenyl)-1-[2]pyridyl-3-pyrrolidino-propan-1-ol 

Relevant articles and documents

Synthesis, characterization, and crystal structures of tris(2-pyridyl) phosphine sulfide and selenide

We report the synthesis and structural determinations of tris(2-pyridyl)phosphine sulfide and selenide, which were prepared by the reaction of 2-lithiopyridine with phosphorus trichloride at -100°C, and treatment of resulted (2-pyridyl)phosphine with elemental sulfur or selenium in hot toluene. These compounds were characterized by elemental analysis, melting point determination, mass spectroscopy, IR, 1H, and 31P NMR spectroscopies. Furthermore, the molecular structures of tris(2-pyridyl)phosphine sulfide and selenide were determined by single crystal X-ray analysis and compared with the structures of tris(2-pyridyl)phosphine and tris(2-pyridyl)phosphine oxide. Copyright Taylor & Francis Group, LLC.

Chemoselective Ketone Synthesis by the Addition of Organometallics to N-Acylazetidines

A general and highly chemoselective method for the synthesis of ketones by the addition of organometallics to N-acylazetidines via stable tetrahedral intermediates is reported for the first time. The transformation is characterized by its wide substrate scope and exquisite selectivity for the ketone products even when a large excess of nucleophilic reagents is used. Even of broader interest is the use of N-acylazetidines as bench-stable, readily available amide acylating reagents, in which the reactivity is controlled by amide pyramidalization and strain of the four-membered ring to afford synthetically valuable building blocks.

Carbon-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists

Disclosed are compounds of the formula or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF or N; Y is —C(═O)—, —C(═S)—, —(CH2)q—, —C(═NOR7)— or —SO1-2—; Z is a bond or optionally substituted alkylene or alkenylene; R1 is H, alkyl, alkenyl, or optionally substituted cycloalkyl, aryl, heteroaryl, heterocycloalkyl or a group of the formula: where ring A is a monoheteroaryl ring; R1 is optionally substituted alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; and the remaining variables are as defined in the specification; compositions and methods of treating allergy-induced airway responses, congestion, obesity, metabolic syndrome nonalcoholic fatty liver disease, hepatic steatosis, nonalcoholic steatohepatitis, cirrhosis, hepatacellular carcinoma or cognition deficit disorders using said compounds, alone or in combination with other agents.