17628-72-7 Usage
Description
(R)-(-)-2-METHOXY-2-PHENYLETHANOL, also known as (R)-(-)-β-Methoxyphenethyl alcohol, is an organic compound with the molecular formula C8H10O2. It is a chiral molecule, which means it has a non-superimposable mirror image, and it belongs to the class of secondary alcohols. (R)-(-)-2-METHOXY-2-PHENYLETHANOL is characterized by its distinct smell, often described as floral or slightly fruity, and is used as a building block in the synthesis of various organic compounds.
Uses
Used in Chemical Synthesis:
(R)-(-)-2-METHOXY-2-PHENYLETHANOL is used as a precursor for the synthesis of various organic compounds, such as (?)-3-[(2R)-2-Methoxy-2-phenylethoxy]phenol, which is a key intermediate in the synthesis of C4-symmetric tetraalkoxy[4]resorcinarenes using a boron trifluoride catalyst. This application is crucial in the development of new materials with potential applications in various industries, including pharmaceuticals and materials science.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (R)-(-)-2-METHOXY-2-PHENYLETHANOL serves as the N-substituent of the 6,7-benzomorphan scaffold, which is used as a potent opioid receptor agonist. This application is significant in the development of new drugs for the treatment of pain and other conditions that require modulation of the opioid receptors.
Used in Polymer Industry:
(R)-(-)-2-METHOXY-2-PHENYLETHANOL is also used as a component in the synthesis of sodium methoxyphenylethoxide (Na-MPE), which is employed as an oxy-initiator in the anionic polymerization of n-hexyl isocyanate. This application is essential in the production of polyurethane materials, which have a wide range of uses in various industries, including automotive, construction, and consumer goods.
Check Digit Verification of cas no
The CAS Registry Mumber 17628-72-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,6,2 and 8 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 17628-72:
(7*1)+(6*7)+(5*6)+(4*2)+(3*8)+(2*7)+(1*2)=127
127 % 10 = 7
So 17628-72-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H12O2/c1-11-9(7-10)8-5-3-2-4-6-8/h2-6,9-10H,7H2,1H3/t9-/m0/s1
17628-72-7Relevant articles and documents
Colombo et al.
, p. 591 (1979)
Stereospecific lewis acid catalyzed methanolysis of styrene oxide
Moberg, Christina,Rakos, Laszlo,Tottie, Louise
, p. 2191 - 2194 (1992)
The methanolysis of (R)-styrene oxide catalyzed by SnCl4 has been found to proceed with complete regioselectivity with nucleophilic attack at the benzylic position, and with inversion of configuration at the benzylic carbon as the predominant stereochemical course, affording (S)-2-methoxy-2-phenylethanol (95% ee) in high yield.
Use of trichloroacetonitrile as a hydrogen chloride generator for ring-opening reactions of aziridines
Toda, Yasunori,Matsuda, Riki,Gomyou, Shuto,Suga, Hiroyuki
supporting information, p. 3825 - 3829 (2019/04/17)
Regioselective ring-opening reactions of 2-aryl-N-tosylaziridines are described, in which hydrogen chloride is generated by photodegradation of trichloroacetonitrile. HCl adducts are obtained in high yields in 1,4-dioxane, whereas methanol adducts are pre
Highly efficient and chemoselective zinc-catalyzed hydrosilylation of esters under mild conditions
Kovalenko, Oleksandr O.,Adolfsson, Hans
supporting information, p. 2785 - 2788 (2015/02/05)
A mild and highly efficient catalytic hydrosilylation protocol for room-temperature ester reductions has been developed using diethylzinc as the catalyst. The methodology is operationally simple, displays high functional group tolerance and provides for a facile access to a broad range of different alcohols in excellent yields.
