176486-63-8 Usage
Description
(2S,4R)-FMOC-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID is a complex organic compound with a solid chemical structure. It is characterized by its stereochemistry, with the 2S,4R configuration, and is derived from the amino acid proline. The compound features a fluorenylmethyloxycarbonyl (Fmoc) protecting group and a tert-butyloxycarbonyl (Boc) protecting group, which are commonly used in peptide synthesis to protect the amino and carboxylic acid functional groups, respectively.
Uses
Used in Pharmaceutical Industry:
(2S,4R)-FMOC-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID is used as a key intermediate in the synthesis of pharmaceutical compounds, specifically for the preparation of NS3-serine protease inhibitors of hepatitis C virus. These inhibitors play a crucial role in the development of antiviral drugs targeting the hepatitis C virus, as they help to block the viral replication process and reduce the viral load in infected individuals.
Used in Peptide Synthesis:
In the field of peptide chemistry, (2S,4R)-FMOC-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID serves as a building block for the synthesis of various peptides and peptide-based drugs. The compound's protected functional groups allow for the stepwise assembly of peptide chains, enabling the creation of complex peptide structures with specific biological activities.
Used in Research and Development:
(2S,4R)-FMOC-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID is also utilized in research and development settings, where it can be employed to study the structure-activity relationships of peptides and their analogs. This knowledge can be applied to the design and development of novel therapeutic agents with improved pharmacological properties and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 176486-63-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,6,4,8 and 6 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 176486-63:
(8*1)+(7*7)+(6*6)+(5*4)+(4*8)+(3*6)+(2*6)+(1*3)=178
178 % 10 = 8
So 176486-63-8 is a valid CAS Registry Number.
InChI:InChI=1/C25H28N2O6/c1-25(2,3)33-24(31)27-13-15(12-21(27)22(28)29)26-23(30)32-14-20-18-10-6-4-8-16(18)17-9-5-7-11-19(17)20/h4-11,15,20-21H,12-14H2,1-3H3,(H,26,30)(H,28,29)/t15-,21+/m1/s1
176486-63-8Relevant articles and documents
INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF
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Paragraph 00319; 00320; 00362; 00363, (2019/02/17)
Provided herein are compounds that inhibit pKal, a serine protease whose activity is responsible for proteolytically cleaving kininogen and generating the potent vasodilator and pro-inflammatory peptide bradykinin, which can lead to painful and debilitating inflammatory attacks (e.g., edema). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating pKal-related diseases and disorders (e.g., edema) with the compounds in a subject, by administering the compounds and/or compositions described herein.
NOVEL PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS
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, (2008/06/13)
The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such peptides as well as methods of using them to treat disorders associated with the HCV protease.
