176708-42-2

Basic information

• Product Name: KN92
• Synonyms: K92;K 92;KN-92 free base;KN-92;KN 92;KN92;N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE;Benzenesulfonamide, N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-4-methoxy-
• CAS NO: 176708-42-2
• Molecular Formula: C24H25ClN2O3S
• Molecular Weight: 456.9849
• Mol File: 176708-42-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 602.1±65.0 °C(Predicted)
• Appearance: /
• Density: 1.282±0.06 g/cm3(Predicted)
• PKA: 8.49±0.10(Predicted)
• CAS DataBase Reference: KN92(CAS DataBase Reference)
• NIST Chemistry Reference: KN92(176708-42-2)
• EPA Substance Registry System: KN92(176708-42-2)

Safety Data

• Hazardous Substances Data: 176708-42-2(Hazardous Substances Data)

Usage

General Description

KN92 is a novel guanylate cyclase (GC) inhibitor that has been identified as a potential neuroprotective agent. It acts by specifically inhibiting the activity of the nitric oxide-sensitive soluble guanylate cyclase (sGC), which is involved in intracellular signaling pathways. By targeting this enzyme, KN92 has demonstrated neuroprotective effects in various models of neurodegenerative diseases and has shown potential for treating conditions such as Parkinson's disease, Alzheimer's disease, and ischemic stroke. Additionally, KN92 has also been found to have anti-inflammatory properties, making it a promising candidate for the development of new therapeutic approaches for neurological disorders.

Upstream product

• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 

Relevant articles and documents

The Crystal Structure of N-[(2E)-3-(4-Chlorophenyl)prop-2-en-1-yl]-4-methoxy-N-methylbenzenesulfonamide

The title compound C17H18ClNO3S crystallizes in the monoclinic P21/c space group with unit cell parameters a = 15.040?(3) ?, b = 9.151 (6)??, c = 13.868 (7)??, β = 116.38 (5)°. Chlorophenyl and methoxyphenyl ring planes are approximately perpendicular and the two moieties form an angle of 82.2°. The crystal packing is stabilized by π–π and Cl–π interactions, which occur between parallel methoxyphenyl and chlorophenyl moieties. Dipolar intermolecular contacts, mainly involving the oxygen atoms and C–H, also contribute to the crystal network. Graphical Abstract: The title compound is formed in the synthetic route for the production of potent inhibitors of calmodulin. Its crystal structure shows the chlorophenyl and methoxyphenyl moieties forming an angle of 82.2°. The crystal packing is stabilized by π–π, Cl–π and dipolar intermolecular contacts. [Figure not available: see fulltext.].