176901-41-0

Basic information

• Product Name: 3-[3N'-(2-chloroethyl)ureido]-3-(3-chlorophenyl)propionic acid
• CAS NO: 176901-41-0
• Molecular Weight: 305.161
• Mol File: 176901-41-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-[3N'-(2-chloroethyl)ureido]-3-(3-chlorophenyl)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[3N'-(2-chloroethyl)ureido]-3-(3-chlorophenyl)propionic acid(176901-41-0)
• EPA Substance Registry System: 3-[3N'-(2-chloroethyl)ureido]-3-(3-chlorophenyl)propionic acid(176901-41-0)

Safety Data

• Hazardous Substances Data: 176901-41-0(Hazardous Substances Data)

Upstream product

• 587-04-2 m-Chlorobenzaldehyde 
• 1943-83-5 2-chloroethyl isothiocyanate 
• 68208-21-9 3-amino-3-(3-chloro-phenyl)-propionic acid 

Downstream Products

• 176901-30-7 3-(2-chloroethyl)-6-(3-chlorophenyl)hexahydropyrimidine-2,4-dione 

Relevant articles and documents

Synthesis and anticonvulsant activity of some new hexahydropyrimidine-2,4- dione derivatives

In this study, twelve new hexahydropyrimidine-2,4-dione derivatives were synthesized and screened for their anticonvulsant activities. All the compounds (7a-l) which have 6-arylhexahydropyrimidine-2,4-dione and N,N-disubstituted dithiocarbamate structures were prepared by the reaction with appropriate 3-(2-chloroethyl)-6-arylhexahydropyrimidine-2,4-diones and the corresponding N,N-disubstituted dithiocarbamate potassium salts. The structure of the synthesized compounds was confirmed by UV, IR, 1H-NMR and elemental analysis. Their anticonvulsant activities were determined by maximal electroshock (MES), subcutaneous pentetrazol (metrazol, scMet) and rotorod toxicity tests for neurological deficits. According to the activity studies, 6-(4-chlorophenyl)hexahydropyrimidine-2,4-dione derivatives (7e-h) were found to be highly protective against MES and scMet. Neurotoxicity was not observed in any of the tested compounds.