176966-56-6

Basic information

• Product Name: (2R,4R,1'S)-1-(1'-phenylethyl)-4-hydroxy-proline methyl ester
• Synonyms: (2R,4R,1'S)-1-(1'-phenylethyl)-4-hydroxy-proline methyl ester
• CAS NO: 176966-56-6
• Molecular Weight: 249.31
• Mol File: 176966-56-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,4R,1'S)-1-(1'-phenylethyl)-4-hydroxy-proline methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R,1'S)-1-(1'-phenylethyl)-4-hydroxy-proline methyl ester(176966-56-6)
• EPA Substance Registry System: (2R,4R,1'S)-1-(1'-phenylethyl)-4-hydroxy-proline methyl ester(176966-56-6)

Safety Data

• Hazardous Substances Data: 176966-56-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 

Downstream Products

• 114676-47-0 (2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl ester 
• 2584-71-6 cis-hydroxy-D-proline 

Relevant articles and documents

Stereoselective synthesis of unnatural aminoacids cis-4-hydroxyproline and bulgecinine

A new stereoselective synthesis of both (2R,4R)- and (2S,4S)-4-hydroxy-proline and (+)- and (-)-bulgecinine was performed starting from synthons 1 or 1', respectively. The synthetic route has been established via a novel assisted cleavage of a disubstituted amide in mild conditions and successive stereocontrolled iodocyclization.