176966-58-8Relevant articles and documents
Stereoselective synthesis of unnatural aminoacids cis-4-hydroxyproline and bulgecinine
Madau, Alessandra,Porzi, Gianni,Sandri, Sergio
, p. 825 - 830 (2007/10/03)
A new stereoselective synthesis of both (2R,4R)- and (2S,4S)-4-hydroxy-proline and (+)- and (-)-bulgecinine was performed starting from synthons 1 or 1', respectively. The synthetic route has been established via a novel assisted cleavage of a disubstituted amide in mild conditions and successive stereocontrolled iodocyclization.