176972-48-8

Basic information

• Product Name: 4-benzylcyclohexanol
• Synonyms: 4-benzylcyclohexanol
• CAS NO: 176972-48-8
• Molecular Weight: 190.285
• Mol File: 176972-48-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-benzylcyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzylcyclohexanol(176972-48-8)
• EPA Substance Registry System: 4-benzylcyclohexanol(176972-48-8)

Safety Data

• Hazardous Substances Data: 176972-48-8(Hazardous Substances Data)

Upstream product

• 101-53-1 p-benzylphenol 
• 81842-24-2 (+/-)-4-benzyl-2-cyclohexenone 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 83631-87-2 8-Benzylidene-1,4-dioxa-spiro[4.5)decane 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 1274805-07-0 4-benzylidenecyclohexanone 
• 1411975-91-1 4-benzylidenecyclohexanol 

Downstream Products

• 1439367-70-0 (2R,3S)-3-hydroxy-2-[({[(1s,4s)-4-benzylcyclohexyl]oxy}carbonyl)amino]butanoic acid 
• 1439367-69-7 (2R,3S)-3-hydroxy-2-[({[(1s,4s)-4-benzylcyclohexyl]oxy}carbonyl)amino]butanoic acid 
• 1439367-67-5 4-benzylcyclohexyl pyridin-2-yl carbonate 
• 1439367-68-6 4-benzylcyclohexyl 2-oxopyridine-1-carboxylate 
• 119185-12-5 diethyl-[2-(4-benzyl-cyclohexyloxy)-ethyl]-amine 
• 107627-54-3 [2-(4-benzyl-cyclohexyloxy)-ethyl]-dimethyl-amine 
• 35883-78-4 3-(4-oxo-1,2,3,4-tetrahydro-[2]naphthyl)-propionic acid 
• 54576-12-4 3-benzyl-adipic acid 
• 35883-77-3 4-benzylcyclohexanone 
• 100544-80-7 4-(cyclohexylmethyl)cyclohexan-1-ol 
• 32386-49-5 3-benzylpentanedioic acid 

Relevant articles and documents

Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3- oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors

N-Acylethanolamine acid amidase (NAAA) is a lysosomal cysteine hydrolase involved in the degradation of saturated and monounsaturated fatty acid ethanolamides (FAEs), a family of endogenous lipid agonists of peroxisome proliferator-activated receptor-α, which include oleoylethanolamide (OEA) and palmitoylethanolamide (PEA). The β-lactone derivatives (S)-N-(2-oxo-3-oxetanyl)-3-phenylpropionamide (2) and (S)-N-(2-oxo-3-oxetanyl)- biphenyl-4-carboxamide (3) inhibit NAAA, prevent FAE hydrolysis in activated inflammatory cells, and reduce tissue reactions to pro-inflammatory stimuli. Recently, our group disclosed ARN077 (4), a potent NAAA inhibitor that is active in vivo by topical administration in rodent models of hyperalgesia and allodynia. In the present study, we investigated the structure-activity relationship (SAR) of threonine-derived β-lactone analogues of compound 4. The main results of this work were an enhancement of the inhibitory potency of β-lactone carbamate derivatives for NAAA and the identification of (4-phenylphenyl)-methyl-N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]carbamate (14q) as the first single-digit nanomolar inhibitor of intracellular NAAA activity (IC50 = 7 nM on both rat NAAA and human NAAA).

Perfume base composition

The present invention relates to a perfume base composition comprising a carrier and a benzyl-substituted cyclohexanol having formula (1), wherein the dashed line denotes an optional double bond and the benzyl group is in the 2-, 3- or 4-position of the c