176982-58-4 Usage
Description
(3-Benzylamino-1-methyl-propyl)-carbamic acid tert-butyl ester is a white to off-white solid chemical compound that belongs to the class of carbamic acid esters. It is soluble in organic solvents and features a tert-butyl ester group, a carbamate group, and a benzylamino-methyl-propyl moiety. (3-BENZYLAMINO-1-METHYL-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER is commonly used in organic synthesis as a reagent and intermediate for the preparation of various pharmaceuticals and agrochemicals. Careful handling and adherence to proper safety protocols are essential when working with this chemical.
Uses
Used in Pharmaceutical Industry:
(3-Benzylamino-1-methyl-propyl)-carbamic acid tert-butyl ester is used as a reagent and intermediate for the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, (3-Benzylamino-1-methyl-propyl)-carbamic acid tert-butyl ester serves as a reagent and intermediate for the preparation of various agrochemicals. Its properties make it suitable for use in the development of pesticides, herbicides, and other agricultural chemicals to improve crop protection and yield.
Check Digit Verification of cas no
The CAS Registry Mumber 176982-58-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,6,9,8 and 2 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 176982-58:
(8*1)+(7*7)+(6*6)+(5*9)+(4*8)+(3*2)+(2*5)+(1*8)=194
194 % 10 = 4
So 176982-58-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H26N2O2/c1-13(18-15(19)20-16(2,3)4)10-11-17-12-14-8-6-5-7-9-14/h5-9,13,17H,10-12H2,1-4H3,(H,18,19)/t13-/m0/s1
176982-58-4Relevant articles and documents
Structure - Immunosuppressive activity relationships of new analogues of 15-deoxyspergualin. 2. Structural modifications of the spermidine moiety
Lebreton, Luc,Jost, Eric,Carboni, Bertrand,Annat, Jocelyne,Vaultier, Michel,Dutartre, Patrick,Renaut, Patrice
, p. 4749 - 4763 (2007/10/03)
A series of new analogues of 15-deoxyspergualin (DSG), an immunosuppressive agent commercialized in Japan, was synthesized and tested in a graft-versus-host disease (GVHD) model in mice. Various substitutions of the spermidine 'D' region were made in order to determine its optimum structure in terms of in vivo immunosuppressive activity. Various positions of methylation were first investigated leading to the discovery of the monomethylated malonic derivative 56h in which the pro-R hydrogen of the methylene α to the primary amine of the spermidine moiety has been replaced by a methyl group. Synthesis of the similarly methylated analogue of the previously reported glycolic derivative LF 08-0299 afforded 60c which demonstrated a powerful activity at a dose as low as 0.3 mg/kg in the GVHD model and was much more potent than DSG in the demanding heart allotransplantation model in rats. The improvement of in vivo activity was supposed to be related to an increase of the metabolic stability of the methylated analogues compared to the parent molecules. Due to its very low active dose, compatible with a subcutaneous administration in humans, and its favorable pharmacological and toxicological profile, 60e was selected as a candidate for clinical evaluation.