177036-78-1 Usage
Description
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid methyl ester, also known as (S)-α-Hydroxy-β-methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester, is an organic compound with a unique chemical structure characterized by a chiral center at the 2nd carbon atom. It is a derivative of propionic acid with hydroxy, methoxy, and diphenyl groups attached to the 2nd and 3rd carbon atoms, respectively. (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid methyl ester is known for its role as an impurity in the synthesis of Ambrisentan, a nonpeptide endothelin ETA receptor antagonist with antihypertensive properties.
Uses
Used in Pharmaceutical Industry:
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid methyl ester is used as an impurity in the synthesis of Ambrisentan (A575860) for its role as a nonpeptide endothelin ETA receptor antagonist. The compound contributes to the development of antihypertensive drugs, which are essential in managing high blood pressure and related cardiovascular conditions.
Used in Drug Synthesis:
In the field of drug synthesis, (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid methyl ester serves as a key intermediate or impurity in the production of Ambrisentan Hydroxyester Impurity. This impurity is crucial for the development and optimization of the synthesis process, ensuring the purity and efficacy of the final drug product.
Check Digit Verification of cas no
The CAS Registry Mumber 177036-78-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,7,0,3 and 6 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 177036-78:
(8*1)+(7*7)+(6*7)+(5*0)+(4*3)+(3*6)+(2*7)+(1*8)=151
151 % 10 = 1
So 177036-78-1 is a valid CAS Registry Number.
177036-78-1Relevant articles and documents
PROCESS FOR THE PREPARATION OF AN ENDOTHELIN RECEPTOR ANTAGONIST
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Page/Page column 20-21, (2013/05/09)
The present invention relates to a novel process for the preparation of a compound of formula (I) wherein R is a methyl or methoxy group; to certain novel intermediates prepared in such a process and their use.
Kinetic resolution of racemic α-tert-alkyl-α-hydroxy esters by enantiomer-selective carbamoylation
Kurono, Nobuhito,Ohtsuga, Kentaro,Wakabayashi, Masanori,Kondo, Tadahiro,Ooka, Hirohito,Ohkuma, Takeshi
experimental part, p. 10312 - 10318 (2012/01/30)
Kinetic resolution of sterically hindered racemic α-tert-alkyl- α-hydroxy esters is performed by enantiomer-selective carbamoylation with the t-Bu-Box-Cu(II) catalyst (Box = bis-(oxazoline)). The reaction with 0.5 equiv of n-C3H7NCO is carried out with a substrate-to-catalyst molar ratio of 500-5000 at -20 to 25 °C. The high enantiomer-discrimination ability of the catalyst achieves an excellent stereoselectivity factor (s = kfast/kslow) of 261 in the best case. A catalytic cycle for this reaction is proposed (Figure presented).
Azinyloxy, and phenoxy-diaryl-carboxylic acid derivatives, their preparation and use as mixed ETA/ETB endothelin receptor antagonists
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Page column 16, (2010/02/05)
The invention relates to carboxylic acid derivatives of the formula I where the radicals have the meanings stated in the description, and to their use as drugs.