17708-83-7

Basic information

• Product Name: L-Proline, 1-[1-[(phenylmethoxy)carbonyl]-L-prolyl]-, methyl ester
• CAS NO: 17708-83-7
• Molecular Formula: C19H24N2O5
• Molecular Weight: 360.41
• Mol File: 17708-83-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: L-Proline, 1-[1-[(phenylmethoxy)carbonyl]-L-prolyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 1-[1-[(phenylmethoxy)carbonyl]-L-prolyl]-, methyl ester(17708-83-7)
• EPA Substance Registry System: L-Proline, 1-[1-[(phenylmethoxy)carbonyl]-L-prolyl]-, methyl ester(17708-83-7)

Safety Data

• Hazardous Substances Data: 17708-83-7(Hazardous Substances Data)

Upstream product

• 2133-40-6 L-proline methyl ester monohydrochloride 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 77-76-9 2,2-dimethoxy-propane 
• 7360-23-8 Cbz-Pro-Pro-OH 
• 147-85-3 L-proline 
• 26607-48-7 1-benzyl hydrogen (S)-pyrrolidine-1,2-dicarboxylate, compound with dicyclohexylamine (1:1) 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 3304-59-4 N-benzyloxycarbonyl-L-proline p-nitrophenyl ester 

Downstream Products

• 1241905-64-5 C₂₂H₃₂N₂O₄ 
• 1241905-63-4 C₃₄H₂₈F₁₂N₂O₄ 
• 7360-23-8 Cbz-Pro-Pro-OH 
• 117928-94-6 benzyl (S)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-1-((S)-1-((2S,3R)-2-amino-3-hydroxybutanoyl)pyrrolidine-2 carbonyl)pyrrolidine-2-carboxamide 
• 148205-63-4 Z-Pro-Pro-Arg(NO₂)-Pro-OBzl 
• 148205-62-3 Z-Pro-Pro-NHNH₂ 
• 86925-98-6 Cbz-Pro-prolinol 
• 66283-23-6 (2S,2'S)-2-hydroxymethyl-1-<(1-methylpyrrolidine-2-yl)methyl>pyrrolidine 

Relevant articles and documents

PROCESS AND INTERMEDIATES FOR SYNTHESIS OF PEPTIDE COMPOUNDS

Disclosed is a new process and intermediates for preparing dipyrrolidine peptide compounds such as, for example, rapastinel. Advantageously, the process may be industrially scalable and cost-effective and use less toxic reagents and/or solvents. Further, the process may be used to prepare peptide compounds having improved purity.

A mechanochemical approach to access the proline-proline diketopiperazine framework

Ball milling was exploited to prepare a substituted proline building block by mechanochemical nucleophilic substitution. Subsequently, the mechanocoupling of hindered proline amino acid derivatives was developed to provide proline-proline dipeptides under solvent-free conditions. A deprotection-cyclization sequence yielded the corresponding diketopiperazines that were obtained with a high stereoselectivity which could be explained by DFT calculations. Using this method, an enantiopure disubstituted Pro-Pro diketopiperazine was synthesized in 4 steps, making 5 new bonds using a ball mill.

Structures, sensory activity, and dose/response functions of 2,5-diketopiperazines in roasted cocoa nibs (Theobroma cacao)

The taste compounds inducing the blood-like, metallic bitter taste sensation reported recently for a dichloromethane extract prepared from roasted cocoa nibs were identified as a series of 25 diketopiperazines by means of HPLC degustation, LC-MS/MS, and i