1774-35-2

Basic information

• Product Name: 4,4'-Dimethyldiphenylsulfoxide
• Synonyms: 1,1’-sulfinylbis(4-methyl-benzen;1,1’-sulfinylbis-p-toluen;1-Methyl-4-[(4-methylphenyl)sulfinyl]benzene;4,4'-Ditolyl sulfoxide;Ditolyl sulfoxide;Ditolyl sulphoxide;ditolylsulfoxide;ditolylsulphoxide
• CAS NO: 1774-35-2
• Molecular Formula: C₁₄H₁₄OS
• Molecular Weight: 230.33
• EINECS: 217-203-7
• Product Categories: Organic Building Blocks;Sulfoxides;Sulfur Compounds;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds
• Mol File: 1774-35-2.mol
• Article Data: 51

Chemical Properties

• Melting Point: 94-96 °C(lit.)
• Boiling Point: 378.3 °C at 760 mmHg
• Flash Point: 182.6 °C
• Appearance: /
• Density: 1.19 g/cm³
• Vapor Pressure: 1.39E-05mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: 4,4'-Dimethyldiphenylsulfoxide(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-Dimethyldiphenylsulfoxide(1774-35-2)
• EPA Substance Registry System: 4,4'-Dimethyldiphenylsulfoxide(1774-35-2)

Safety Data

• WGK Germany: 3
• RTECS: XT4810000
• Hazardous Substances Data: 1774-35-2(Hazardous Substances Data)

Usage

General Description

4,4'-Dimethyldiphenylsulfoxide, also known as DMSO, is a chemical compound that is often used as a solvent and a reagent in organic synthesis. It is an organosulfur compound that contains two phenyl groups and two methyl groups attached to a sulfur atom with an oxygen atom. DMSO is a colorless liquid that is soluble in a wide range of polar and nonpolar solvents, making it a versatile substance in chemical reactions. It has a wide range of industrial and laboratory applications, including in the production of pharmaceuticals, polymers, and agrochemicals. Additionally, DMSO has been investigated for its potential medicinal properties, as it has been proposed to have anti-inflammatory, antimicrobial, and analgesic effects. However,

InChI:InChI=1/C14H14OS/c1-11-3-7-13(8-4-11)16(15)14-9-5-12(2)6-10-14/h3-10H,1-2H3

Upstream product

• 462-06-6 fluorobenzene 
• 108-88-3 toluene 
• 455-16-3 p-toluenesulfonyl fluoride 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 60288-40-6 trimethylsulfonium triflate 
• 109528-06-5 Trifluoro-methanesulfonatetrimethyl-selenonium; 
• 109528-18-9 Trifluoro-methanesulfonatetrimethyl-telluronium; 
• 16491-20-6 (R)-1-methyl-4-(phenylsulfinyl)benzene 
• 108-86-1 bromobenzene 
• 136378-30-8 2-(p-tolylsulfinyl)naphthalene 
• 594-19-4 tert.-butyl lithium 
• 77096-69-6 1-benzenesulfinyl-4-methyl-benzene 
• 620-94-0 di-(p-tolyl)sulfane 
• 4294-57-9 para-methylphenylmagnesium bromide 

Downstream Products

• 10381-70-1 benzyl 4-methylphenyl sulfoxide 
• 22417-22-7 tris(4-methylphenyl)sulfonium chloride 
• 111661-88-2 Bis(4-methylphenyl)(1-oxo-2-indanyl)sulfonium-perchlorat 
• 89279-86-7 S,S-di-p-tolyl-N-(p-tolylsulfonyl)sulfoximine 
• 83373-32-4 4-Guanidinomethyl-cyclohexanecarboxylic acid p-tolyl ester; hydrochloride 
• 620-94-0 di-(p-tolyl)sulfane 
• 599-66-6 bis(4-methylphenyl) sulfone 
• 95-57-8 2-monochlorophenol 
• 106-48-9 4-chloro-phenol 

Relevant articles and documents

Racemic and optically active 1,1′-binaphthyl-2,2′-diyl sulfite: Synthesis, crystal structure, and ring-opening reactions with selected nucleophiles

Preparation of the sulfite derived from racemic and (R)-(+)-enantiomer of BINOL is reported. The crystal structure of the optically active, levorotatory sulfite isomer and its ring opening induced by nucleophilic substitution reactions with selected nucleophiles are presented.

Lithium/Sodium Perchlorate Catalyzed Synthesis of Symmetrical Diaryl Sulfoxides

Synthesis of diaryl sulfoxides from aromatics and thionyl chloride catalyzed by LiClO4/NaClO4 at room temperature is described. Mild reaction conditions, simple work-up, inexpensive and easily available catalysts are important and attractive features of this method.

Selective synthesis of sulfoxides and sulfonesviacontrollable oxidation of sulfides withN-fluorobenzenesulfonimide

A practical and mild method for the switchable synthesis of sulfoxides or sulfonesviaselective oxidation of sulfides using cheapN-fluorobenzenesulfonimide (NFSI) as the oxidant has been developed. These highly chemoselective transformations were simply achieved by varying the NFSI loading with H2O as the green solvent and oxygen source without any additives. The good functional group tolerance makes the strategy valuable.

Synergistic cooperative effect of CF3SO2Na and bis(2-butoxyethyl)ether towards selective oxygenation of sulfides with molecular oxygen under visible-light irradiation

A safe, practical and eco-friendly method for the switchable synthesis of sulfoxides and sulfones through visible-light-initiated oxygenation of sulfides at ambient temperature under transition-metal-, additives-free and minimal solvent conditions. The synergistic catalytic efforts between CF3SO2Na and 2-butoxyethyl ether represents the key promoting factor for the reaction. This journal is