177703-41-2

Basic information

• Product Name: 5-(4-nitro-benzylidene)-thiazolidine-2,4-dione
• Synonyms: 5-(4-nitro-benzylidene)-thiazolidine-2,4-dione
• CAS NO: 177703-41-2
• Molecular Weight: 250.235
• Mol File: 177703-41-2.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: 5-(4-nitro-benzylidene)-thiazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-nitro-benzylidene)-thiazolidine-2,4-dione(177703-41-2)
• EPA Substance Registry System: 5-(4-nitro-benzylidene)-thiazolidine-2,4-dione(177703-41-2)

Safety Data

• Hazardous Substances Data: 177703-41-2(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 2295-31-0 thiazoline-2,4-dione 
• 41468-11-5 sodium hydroxy(4-nitrophenyl)methanesulfonate 

Downstream Products

• 85003-57-2 5-(4-nitrobenzyl)-1,3-thiazolidine-2,4-dione 
• 1442655-47-1 N-(4-((Z)-(3-(4-tert-butylbenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-2-bromoacrylamide 
• 1442655-46-0 N-(4-((Z)-(3-(4-methylbenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-2-bromoacrylamide 
• 1442655-45-9 N-(4-((Z)-(3-(4-trifluoromethylbenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-2-bromoacrylamide 
• 1442655-44-8 N-(4-((Z)-(3-(3-chlorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-2-bromoacrylamide 
• 1442655-43-7 N-(4-((Z)-(3-(4-chlorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-2-bromoacrylamide 
• 1442655-42-6 N-(4-((Z)-(3-(3-fluorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-2-bromoacrylamide 
• 1442655-41-5 N-(4-((Z)-(3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-2-bromoacrylamide 
• 1442655-40-4 N-(4-((Z)-(3-phenylethyl-2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-2-bromoacrylamide 
• 1442655-39-1 N-(4-((Z)-(3-benzyl-2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-2-bromoacrylamide 
• 1442655-38-0 2-bromo-N-(4-((Z)-(3-ethyl-2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)acrylamide 
• 1442655-37-9 2-bromo-N-(4-((Z)-(3-methyl-2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)acrylamide 
• 1442655-27-7 (Z)-3-(4-tert-butylbenzyl)-5-(4-aminobenzylidene)thiazolidine-2,4-dione 
• 1442655-26-6 (Z)-5-(4-aminobenzylidene)-3-methylthiazolidine-2,4-dione 

Relevant articles and documents

Acetic anhydride-promoted one-pot condensation of 2,4-thiazolidinedione with bisulfite adducts of aldehydes

We describe a simple and efficient one-pot method for condensing bisulfite adducts of aromatic aldehydes directly with 2,4-thiazolidinedione catalyzed by acetic anhydride. The two main highlights of this study are the one-pot condensation of bisulfite adducts with 2,4-thiazolidinedione in non-aqueous media and the use of Design of Experiment to understand and optimize the reaction conditions. This methodology was then generalized using other active methylene compounds, such as malononitrile.

Green synthesis, biological activity evaluation, and molecular docking studies of aryl alkylidene 2, 4-thiazolidinedione and rhodanine derivatives as antimicrobial agents

Aims and Objective: The magic scaffolds rhodanine and thiazolidine are very important heterocyclic compounds in drug design and discovery. Those are important heterocyclic compounds that have attracted a great deal of attention due to the fact that they e

Knoevenagel condensation of aromatic aldehydes with active methylene compounds catalyzed by lipoprotein lipase

A screening of using different lipases to catalyze the Knoevenagel reaction was realized, and lipase lipoprotein (LPL) from Aspergillus niger showed the best catalytic performance. The reaction conditions including solvent, enzyme loading, and temperature were screened to improve the reaction efficiency. Various kinds of substrates were investigated, and almost all the target products were obtained in good to excellent yields (76-98%) with Z configuration exclusively. This procedure provides a novel, green and efficient method for the Knoevenagel condensation of aromatic aldehydes with active methylene compounds.