177839-89-3Relevant articles and documents
Practical asymmetric synthesis of Sitagliptin phosphate monohydrate
Gao, Haoling,Yu, Jiangang,Ge, Chengsheng,Jiang, Qun
, (2018)
Optically pure sitagliptin phosphate monohydrate is efficiently and practically synthesized through a chiral hemiacetal as the key intermediate in 54% overall yield starting from (E)-4-(2,4,5-trifluorophenyl)but-2-enal and N-boc-protected hydroxylamine. The chiral hemiacetal fragment is constructed by a tandem aza-Michael/hemiacetal reaction catalyzed by an organocatalyst and the influence of acidity of Br?nsted acid on tandem aza-Michael/hemiacetal reaction is researched in detail.
Inhibitors of farnesyl protein transferase
-
, (2008/06/13)
Disclosed are quinoline and benzazepine derivatives that inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogenic protein Ras. Thus, the compounds are useful as anti-cancer agents. The compounds are also useful in the treatment of diseases other than cancer.
A novel approach to homochiral β-amino acids 1
Seki, Masahiko,Matsumoto, Kazuo
, p. 3165 - 3168 (2007/10/03)
An efficient synthesis of γ-aryl or alkyl substituted β-amino acids starting from N-Cbz-L-homoserine lactone via the formation of α-amino aryl, alkenyl or alkynyl ketones with the original α-carbon chirality retained as such is described. Copyright