17789-33-2Relevant articles and documents
A Novel Microwave-assisted One-pot Synthesis of Pyrano[2,3-d]pyrimidines and Pyrido[2,3-d]pyrimidines via a Three Component Reaction in Solvent-Free Condition
Devi, Ipsita,Bhuyan, Pulak J.
, p. 283 - 286 (2004)
Three-component cyclocondensation of barbituric acids 1, triethylorthoformate 2 and alkyl nitriles 3 in presence of acetic anhydride proceeds under microwave-assisted conditions to give pyrano[2,3-d]pyrimidines 4 in excellent yields. 6-Aminouracils 5 or 6-hydroxy-aminouracils 7 react with 2 and 3 under identical conditions to yield pyrido[2,3-d]pyrimidines 6 or pyrido[2,3-d]pyrimidine oxides 8 in high yields.
A one-pot synthesis of pyrido[2,3-d]- and quinolino[2,3-d]pyrimidines
El-Ahl, Abdel Aziz S.,El Bialy, Serry A.A.,Ismail, Mohamed A.
, p. 1315 - 1321 (2007/10/03)
The in situ formed methylene derivatives of 1,3-dicarbonyl compounds; ethyl cyanoacetate; malononitrile and ketones; react with 6-amino-1,3-dimethyluracil as activated alkenyl derivatives, affording Michael adducts. The adduts simultaneously undergo cyclization to furnish pyrido[2,3-d]- or quinolino[2,3-d]pyrimidine derivatives in high yield.
Pyrido[2,3-d]pyrimidines and pyrido[2,3-d; 5-d']dipyrimidines as potential chemotherapeutic agents
Ram,Vanden Berghe,Vlietinck
, p. 217 - 219 (2007/10/02)
-
