17790-81-7Relevant articles and documents
SYNTHESIS OF DIMETHYL β-OXOADIPATE
Zav'yalev, S. I.,Zavozin, A. G.,Kravchenko, N. E.
, p. 1104 - 1106 (1991)
Acetoacrtic ester and Meldrum's acid provide a new and simple synthesis of dimethyl β-oxoadipate.This compounds is a synthone for some natural and biologically active compounds.
Synthesis, spectral properties and evaluation of carboxy-functionalized 3-thiazolylcoumarins as blue-emitting fluorescent labeling reagents
Dubey, Igor,Dubey, Larysa,Kuziv, Iaroslav
, (2020)
A series of UV-light excitable 7-hydroxy-, methoxy- and acetoxy-substituted [3-(thiazol-2-yl)]coumarin derivatives containing a carboxyalkyl functional group on the thiazole fragment were synthesized for the fluorescent labeling of biomolecules. The spectral properties of these compounds in methanol and aqueous buffers (pH 6.3 and 10.5) were studied. The dyes exhibit a bright blue fluorescence with maxima in the range of 438–457 nm and large Stokes shifts of 72–83 nm (in methanol). Emission maxima of the ionized forms of the 7-hydroxyl derivatives in basic medium are located at 482–484 nm. Thiazolylcoumarins are characterized by high fluorescence quantum yields (up to 0.85). Dye conjugates with L-trileucine and (2′-5′)-triadenylate were obtained via the active ester approach.
Method for preparing cefcapene side chain acid
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Paragraph 0023; 0029; 0030, (2017/07/20)
The invention relates to a method for preparing cefcapene side chain acid, and belongs to the technical field of refined medical intermediates. The method comprises the following steps: adding ketene dimer into an alcohol organic solvent in the presence of nitrogen, dropwise adding bromine for reaction, adding a mixed liquid of dichloromethane and water for quenching reaction, separating an organic phase, adding acetic acid into the organic phase, dropwise adding propyl aldehyde and an organic alkali catalyst A for reaction, then adding thiourea for reaction, performing vacuum distillation for concentration, adding dichloromethane, di-tert-butyl dicarbonate ester and an organic alkali catalyst B into a concentrated solution for reaction, adding a caustic soda liquid for reaction, cooling, dropwise adding hydrochloric acid for crystallization, filtering, performing drip washing with an isopropanol solution, and drying, thereby obtaining (Z)-2-(2-t-butyloxycarboryl aminothiazole-4-yl)-2-pentenoic acid, that is, the cefcapene side chain acid. As the ketene dimer is adopted as an initial raw material, the method is small in side reaction, high in yield, high in purity of obtained products and gentle in reaction condition, and industrial production can be relatively easily achieved.
Development of new thiazole-based iridium catalysts and their applications in the asymmetric hydrogenation of trisubstituted olefins
Cheruku, Pradeep,Paptchikhine, Alexander,Ali, Muhammad,Neudoerfl, Joerg-M.,Andersson, Pher G.
, p. 366 - 373 (2008/10/09)
New thiazole-based chiral N,P-ligands that are open-chain analogues of known cyclic thiazole ligands have been synthesized and evaluated in the iridium-catalyzed asymmetric hydrogenation of trisubstituted olefins. Chirality was introduced into the ligands through a highly diastereoselective alkylation using Oppolzer's camphorsultam as chiral auxiliary. In general, the new catalysts are as reactive and selective as their cyclic counterparts for the asymmetric hydrogenation of various trisubstituted olefins. This journal is The Royal Society of Chemistry.
