177938-27-1

Basic information

• Product Name: 5-hydroxy-3-methyl-2(1H)-quinolinone
• CAS NO: 177938-27-1
• Molecular Weight: 175.187
• Mol File: 177938-27-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 396.6±42.0 °C(Predicted)
• Density: 1.264±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 5-hydroxy-3-methyl-2(1H)-quinolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxy-3-methyl-2(1H)-quinolinone(177938-27-1)
• EPA Substance Registry System: 5-hydroxy-3-methyl-2(1H)-quinolinone(177938-27-1)

Safety Data

• Hazardous Substances Data: 177938-27-1(Hazardous Substances Data)

Upstream product

• 77903-18-5 3-methyl-1,2,3,4,5,6,7,8-octahydroquinoline-2,5-dione 

Relevant articles and documents

Metallation of methoxy-2(1H)-quinolinones

Methoxy group at 5- or 6-position of 2(1H)-quinolinones is compatible with the regioselective electrophilic substitution and chain enlargement at the 3-position imposed by the ortho-directed effect of the quinolinone lithium salt. The coordination effect of a methoxy group at the 8- position changes the reaction course, precluding the ortho-directed metallation and enhancing the conjugate addition at the 4- position.