177944-29-5Relevant articles and documents
Chiral Analogues of PFI-1 as BET Inhibitors and Their Functional Role in Myeloid Malignancies
Altenburg, Bianca,Frings, Marcus,Sch?bel, Jan-Hendrik,Go?en, Jonas,Pannen, Kristina,Vanderliek, Kim,Rossetti, Giulia,Koschmieder, Steffen,Chatain, Nicolas,Bolm, Carsten
, p. 1928 - 1934 (2020/11/09)
Structural analogues of PFI-1 varying at the sulfur core were prepared, and their activities as BET inhibitors in myeloid cell lines and primary cells from patients with acute myeloid leukemia were studied. Docking calculations followed by molecular dynam