17797-09-0

Basic information

• Product Name: 2-(4-TERT-BUTYLPHENYL)PROPAN-2-AMINE
• Synonyms: 2-(4-TERT-BUTYLPHENYL)PROPAN-2-AMINE
• CAS NO: 17797-09-0
• Molecular Formula: C13H21N
• Molecular Weight: 191.31
• Mol File: 17797-09-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-TERT-BUTYLPHENYL)PROPAN-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-TERT-BUTYLPHENYL)PROPAN-2-AMINE(17797-09-0)
• EPA Substance Registry System: 2-(4-TERT-BUTYLPHENYL)PROPAN-2-AMINE(17797-09-0)

Safety Data

• Hazardous Substances Data: 17797-09-0(Hazardous Substances Data)

Usage

Chemical classification

Substituted amphetamine compound

Potential effects

Stimulant and psychoactive effects

Mechanism of action

Selective norepinephrine-dopamine releasing agent

Structural features

tert-butyl group on phenyl ring, amine group

Stability

Non-reactivity due to tert-butyl group

Bioavailability

Enhanced due to amine group

Central nervous system effects

Potential for effects on the CNS

Field of interest

Pharmacology and toxicology

Therapeutic uses

Potential for therapeutic uses

Recreational uses

Potential for recreational uses

Potential for abuse and addiction

May have potential for abuse and addiction.

Upstream product

• 4210-32-6 4-tert-butyl benzonitrile 
• 917-54-4 methyllithium 
• 4132-49-4 p-tert.-Butyl-cumol 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 1443144-13-5 N-(2-(4-tert-butylphenyl)propan-2-yl)picolinamide 

Relevant articles and documents

Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent

The optimization campaign for a nitrofuran antitubercular hit (N-benzyl-5-nitrofuran-2-carboxamide; JSF-3449) led to the design, synthesis, and biological profiling of a family of analogs. These compounds exhibited potent in vitro antitubercular activity (MIC = 0.019–0.20 μM) against the Mycobacterium tuberculosis H37Rv strain and low in vitro cytotoxicity (CC50 = 40–>120 μM) towards Vero cells. Significant improvements in mouse liver microsomal stability and mouse pharmacokinetic profile were realized by introduction of an α α-dimethylbenzyl moiety. Among these compounds, JSF-4088 is highlighted due to its in vitro antitubercular potency (MIC = 0.019 μM) and Vero cell cytotoxicity (CC50 > 120 μM). The findings suggest a rationale for the continued evolution of this promising series of antitubercular small molecules.