177980-14-2

Basic information

• Product Name: 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamido-3'-(2-cyanoethyl-N,N-diisopropylamino)phosphinyl-2'-deoxyuridine
• CAS NO: 177980-14-2
• Molecular Weight: 831.86
• Mol File: 177980-14-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamido-3'-(2-cyanoethyl-N,N-diisopropylamino)phosphinyl-2'-deoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamido-3'-(2-cyanoethyl-N,N-diisopropylamino)phosphinyl-2'-deoxyuridine(177980-14-2)
• EPA Substance Registry System: 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamido-3'-(2-cyanoethyl-N,N-diisopropylamino)phosphinyl-2'-deoxyuridine(177980-14-2)

Safety Data

• Hazardous Substances Data: 177980-14-2(Hazardous Substances Data)

Upstream product

• 26929-65-7 2'-azido-2'-deoxyuridine 
• 26889-39-4 1-(2-amino-2-deoxy-β-D-ribofuranosyl)uracil 
• 51989-21-0 (2R,3R,4S,5R)-N-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl)-2,2,2-trifluoroacetamide 
• 118849-17-5 5'-O-(4,4'-dimethoxytrityl)-2'-(trifluoroacetylamido)-2'-deoxyuridine 
• 174221-86-4 5'-O-dimethoxytrityl-2'-amino-2'-deoxyuridine 

Downstream Products

• 177980-15-3 C₆₇H₆₇N₆O₁₉P 

Relevant articles and documents

Monomers for oligonucleotide synthesis with linkers carrying reactive residues: II. The synthesis of phosphoamidites on the basis of uridine and cytosine and containing a linker with methoxyoxalamide groups in position 2′

A convenient preparative synthesis of 2′-amino-2′-deoxyuridine was developed. Starting from 2′-amino-2′-deoxyuridine and 2′-amino-2′-deoxycytidine, monomers for the phosphoamidite oligonucleotide synthesis were obtained that carry a linker with methoxyoxalamide groups in position 2′.