1780-42-3

Basic information

• Product Name: 2,4,6-trichloro-5-isopropylpyriMidine
• Synonyms: 2,4,6-trichloro-5-isopropylpyriMidine;PyriMidine, 2,4,6-trichloro-5-(1-Methylethyl)-
• CAS NO: 1780-42-3
• Molecular Formula: C₇H₇Cl₃N₂
• Molecular Weight: 225.50288
• Mol File: 1780-42-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 243.8ºC at 760 mmHg
• Flash Point: 124.8ºC
• Appearance: /
• Density: 1.393g/cm3
• Vapor Pressure: 0.0492mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,4,6-trichloro-5-isopropylpyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-trichloro-5-isopropylpyriMidine(1780-42-3)
• EPA Substance Registry System: 2,4,6-trichloro-5-isopropylpyriMidine(1780-42-3)

Safety Data

• Hazardous Substances Data: 1780-42-3(Hazardous Substances Data)

Usage

General Description

2,4,6-trichloro-5-isopropylpyriMidine is a chemical compound with the molecular formula C8H10Cl3N3. It is a white crystalline solid that is used as a building block in the synthesis of pharmaceuticals and agrochemicals. This chemical is also known for its application as a fungicide and acaricide in agriculture. It is highly soluble in organic solvents and has a low solubility in water. As a result, it is often used as a component in pesticides and herbicides to control fungal and pest infestations in crops. Additionally, it is used as an intermediate in the synthesis of various organic compounds and is an important molecule in the field of organic chemistry.

InChI:InChI=1/C7H7Cl3N2/c1-3(2)4-5(8)11-7(10)12-6(4)9/h3H,1-2H3

Upstream product

• 7391-69-7 5-isopropylbarbaric acid 
• 7391-69-7 5-isopropylbarbituric acid 
• 108-20-3 di-isopropyl ether 
• 759-36-4 diethyl isopropylmalonate 

Downstream Products

• 171048-77-4 2,4-dichloro-6-(3,5-dimethyl-phenoxy)-5-isopropyl-pyrimidine 
• 1006301-22-9 4-chloro-5-isopropyl-2,6-bis-(4-methoxy-benzyloxy)-pyrimidine 
• 1006302-21-1 2,4-dichloro-5-isopropyl-6-(2,3,5-trimethyl-phenoxy)-pyrimidine 
• 1006302-65-3 (3-cyano-5-methyl-phenyl)-(2,6-dichloro-5-isopropyl-pyrimidin-4-yl)-carbamic acid tert-butyl ester 
• 1006302-74-4 2,4-bis(benzyloxy)-6-chloro-5-isopropylpyrimidine 
• 1310053-32-7 6-[4-(2-methoxyphenyl)-1-piperazinyl]-5-isopropyluracil 
• 1310053-31-6 6-(4-phenyl-1-piperazinyl)-5-isopropyluracil 
• 1006300-37-3 3-(2,6-Dichloro-5-isopropyl-pyrimidin-4-yloxy)-5-methyl-benzonitrile 
• 291275-22-4 2,4-dichloro-5-isopropyl-6-[N-(3',5'-dimethylphenyl)formylamido]pyrimidine 
• 225232-14-4 6-benzyl-2,4-dichloro-5-isopropylpyrimidine 
• 171048-69-4 6-(3,5-dimethylbenzyl)-5-isopropyl-2,4-pyrimidinedione 
• 225232-60-0 2,4-dimethoxy-6-(3,5-dimethylbenzyl)-5-isopropylpyrimidine 
• 225232-58-6 6-benzyl-2,4-dimethoxy-5-isopropylpyrimidine 
• 176519-55-4 6-benzyl-5-isopropylpyrimidine-2,4(1H,3H)-dione 

Relevant articles and documents

1,1,1-TRICHLORO-3--3,4-EPOXYBUTANE

The synthesis of 1,1,1-trichloro-3--3,4-epoxybutane has been accomplished in nine steps from diethyl malonate and urea.The epoxide was prepared from the olefinic precursor via oxidation with anhydrous trifluoroperacetic acid in a non-buffered system.Product isolation from trifluoroacetic acid solution demonstrates an unexpected stability of this class of epoxides toward protonic media.

HETEROCYCLIC INHIBITORS OF KDM5 FOR THE TREATMENT OF DISEASE

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N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase

A series of N1-alkyl pyrimidinediones were designed, synthesized and evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Our efforts identified compound 10b, which represents the lead compound in this series with pharmacokinetics