178043-45-3Relevant articles and documents
Study of the synthesis, antiviral bioactivity and interaction mechanisms of novel chalcone derivatives that contain the 1,1-dichloropropene moiety
Dong, Liang-Run,Hu, De-Yu,Wu, Zeng-Xue,Chen, Ji-Xiang,Song, Bao-An
, p. 1566 - 1570 (2017/07/17)
A series of novel chalcone derivatives that contain the 1,1-dichloropropene moiety was designed and synthesized. Bioactivity assays showed that most of the target compounds exhibited moderate to good antiviral activity against tobacco mosaic virus (TMV) at 500?μg/mL. Among the target compounds, compound 7h showed the highest in vivo inactivation activity against TMV with the EC50 and EC90 value of 45.6 and 327.5?μg/mL, respectively, which was similar to that of Ningnanmycin (46.9 and 329.4?μg/mL) and superior to that of Ribavirin (145.1 and 793.1?μg/mL). Meanwhile, the microscale thermophoresis and fluorescence spectroscopy experiments showed that the compound 7h had a strong interaction with the tobacco mosaic virus coat protein.
Chalcone derivate with 1,1-dichloropropene and preparation method and application thereof
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, (2016/10/08)
The invention discloses a chalcone derivate with 1,1-dichloropropene and a preparation method and application thereof. The general structural formula of the chalcone derivate is shown in the description. R is a benzene ring, a substituted aromatic ring and a heterocyclic ring, the ortho-position, meta-position and para-position of the aromatic ring contain one or more of methyl, methoxyl, trifluoromethyl, trifluoromethoxy, nitryl and halogen atoms, halogen atoms can be fluorine, chlorine and bromine, and the heterocyclic ring is a five-membered heterocyclic ring. The chalcone derivate with the 1,1-dichloropropene can improve biological activity, is low in toxicity and environmentally friendly and can be used for pesticides used for preventing and treating the tobacco mosaic virus.
Ether Compounds with Nitrogen-Containing 5-Member Heterocycle and Uses Thereof
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Page/Page column 21, (2011/08/04)
The invention relates to ether compounds with nitrogen-containing 5-member heterocycle, represented by formula (I): The groups are as defined as specification. The compounds of the present invention have broad-spectrum insecticidal activities, and they ar