178270-85-4Relevant articles and documents
Bis-alkylamine quindolone derivatives as new antimalarial leads
Lavrado, Jo?o,Gani, Kaamil,Nobre, Pedro A.,Santos, Sofia A.,Figueiredo, Paula,Lopes, Dinora,Rosário, Virgílio Do,Gut, Jiri,Rosenthal, Philip J.,Moreira, Rui,Paulo, Alexandra
, p. 5634 - 5637 (2010)
Quindolone derivatives, designed to target the malaria parasite digestive vacuole and heme detoxification pathway, have been synthesized by reaction with 2-chloro-N,N-diethylethanamine. This reaction gave N,O-, N,N- and O-alkylated products containing one
Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains
Lavrado, Joao,Borralho, Pedro M.,Ohnmacht, Stephan A.,Castro, Rui E.,Rodrigues, Cecilia M. P.,Moreira, Rui,Dos Santos, Daniel J.V.A.,Neidle, Stephen,Paulo, Alexandra
, p. 1648 - 1661 (2013/10/21)
G-quadruplex (G4) DNA structures in telomeres and oncogenic promoter regions are potential targets for cancer therapy, and G4 ligands have been shown to modulate telomerase activity and oncogene transcription. Herein we report the synthesis and G4 thermal
