178313-45-6

Basic information

• Product Name: 4-bromo-N-methoxy-N,2-dimethylbenzamide
• Synonyms: 4-bromo-N-methoxy-N,2-dimethylbenzamide
• CAS NO: 178313-45-6
• Molecular Formula: C₁₀H₁₂BrNO₂
• Molecular Weight: 258.11
• Mol File: 178313-45-6.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-bromo-N-methoxy-N,2-dimethylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-N-methoxy-N,2-dimethylbenzamide(178313-45-6)
• EPA Substance Registry System: 4-bromo-N-methoxy-N,2-dimethylbenzamide(178313-45-6)

Safety Data

• Hazardous Substances Data: 178313-45-6(Hazardous Substances Data)

Upstream product

• 68837-59-2 4-bromo-2-methylbenzoic acid 
• 21900-45-8 4-bromo-2-methylbenzoyl chloride 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 

Downstream Products

• 65095-33-2 1-(4-bromo-2-methylphenyl)ethan-1-one 
• 1253045-41-8 C₁₃H₁₅BrO 
• 1393537-68-2 C₃₉H₅₀N₂O₁₀ 
• 1374355-15-3 C₁₀H₁₁Br 
• 1208329-77-4 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid 
• 1208330-70-4 (E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)acrylate 
• 1208330-66-8 4-(3-formyl-1-(4-methoxyphenyl)-1H-pyrrol-2-yl)-3-methylbenzamide 

Relevant articles and documents

PIPERIDINE COMPOUNDS AS PCSK9 INHIBITORS

One aspect of the invention relates to a series of new PCSK9 inhibitor compounds comprising piperidine ring structures, including compounds of formula (I) and/or pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating PCSK9 receptor related diseases comprising administration of one or more compounds of formula (I) or a pharmaceutically acceptable salt thereof.

HEPATITIS C VIRUS INHIBITORS

The present disclosure relates to compounds of formula I, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in th

Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: Pyrrole regioisomers and propionic acid replacement

S-Nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO). GSNO and SNOs are implicated in the pathogenesis of many diseases including those in respiratory, cardiovascular, and gastrointestinal systems. The pyrrole based N6022 was recently identified as a potent, selective, reversible, and efficacious GSNOR inhibitor which is currently undergoing clinical development. We describe here the synthesis and structure-activity relationships (SAR) of novel pyrrole based analogues of N6022 focusing on scaffold modification and propionic acid replacement. We identified equally potent and novel GSNOR inhibitors having pyrrole regioisomers as scaffolds using a structure based approach.