178671-99-3

Basic information

• Product Name: 1-[2-(2,2,2-TRIFLUORO-ETHOXY)-PHENYL]-PIPERAZINE D
• Synonyms: 1-[2-(2,2,2-TRIFLUORO-ETHOXY)-PHENYL]-PIPERAZINE D
• CAS NO: 178671-99-3
• Molecular Formula: C₁₂H₁₅F₃N₂O
• Molecular Weight: 0
• Mol File: 178671-99-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-[2-(2,2,2-TRIFLUORO-ETHOXY)-PHENYL]-PIPERAZINE D(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(2,2,2-TRIFLUORO-ETHOXY)-PHENYL]-PIPERAZINE D(178671-99-3)
• EPA Substance Registry System: 1-[2-(2,2,2-TRIFLUORO-ETHOXY)-PHENYL]-PIPERAZINE D(178671-99-3)

Safety Data

• Hazardous Substances Data: 178671-99-3(Hazardous Substances Data)

Upstream product

• 88-75-5 2-hydroxynitrobenzene 
• 87014-28-6 1-(2,2,2-trifluoroethoxy)-2-nitrobenzene 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 57946-60-8 2-(2',2',2'-trifluoroethoxy)aniline 

Downstream Products

• 186387-84-8 3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-1-propanone 
• 335087-42-8 8-<3-{4-[2-(2,2,2-trifluoroethoxy)-phenyl]-1-piperazinyl}propylcarbamoyl>-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran 
• 335087-78-0 2-phenyl-8-<2-{4-[2-(2,2,2-trifluoroethoxy)-phenyl]-1-piperazinyl}-ethylcarbamoyl>-3-methyl-4-oxo-4H-1-benzopyran 
• 334930-12-0 1-[2-(2,2,2-trifluoroethoxy)-phenyl]-4-[3-(N-phthalimido)-propyl]-piperazine 
• 1025909-31-2 8-Chloro-4-(3-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propylamino)-quinoline-3-carboxylic acid 
• 334930-13-1 1-(3-Aminopropyl)-4-[2-(2,2,2-trifluoroethoxy)-phenyl]-piperazine 
• 186386-09-4 1-benzyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-2,2-dimethylpropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione 
• 592527-80-5 toluene-4-sulfonic acid 2,2-dimethyl-3-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl ester 
• 186387-85-9 3-benzyloxy-2,2-dimethyl-1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propane 
• 186387-86-0 2,2-dimethyl-3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-1-propanol 
• 886206-13-9 C₂₃H₃₄F₃N₃O₃ 
• 186385-55-7 1-benzyl-5-methyl-3-(1-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-ylmethyl}-cyclopropylmethyl)-1H-pyrimidine-2,4-dione 

Relevant articles and documents

NOVEL AMINO- AND IMINO-ALKYLPIPERAZINES

Described are novel amino- and iminoalkyl piperazines having affinity for serotonergic receptors and pharmacological compositions thereof. These compounds and their isomers, including optical isomers, enantiomers, diastereomers, N-oxides, polymorphs, hydr

[3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy]-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists

The present invention relates to novel α 1 -adrenoceptor antagonists of Formula I: STR1 in which: p is 0 or 1;t is 0, 1 or 2;X is O, S or NR 6 (in which R 6 is hydro or (C 1-6)alkyl);Y and Z are independently CH or N;R 1 is hydro, hydroxy, halo, nitro, amino, cyano, (C 1-4)alkylthio, acetylamino, trifluoroacetylamino, methylsulfonylamino, (C 1-6)alkyl, (C 3-6)cycloalkyl, (C 3-6)cycloalkyl (C 1-4)alkyl, oxazol-2-yl, aryl, heteroaryl, aryl (C 1-4)alkyl, heteroaryl (C 1-4)alkyl, (C 1-6)alkyloxy, (C 3-6)cycloalkyloxy, (C 3-6)cycloalkyl (C 1-4)alkyloxy, 2-propynyloxy, aryloxy, heteroaryloxy, aryl (C 1-4)alkyloxy or heteroaryl (C 1-4)alkyloxy (wherein alkyl is optionally substituted with one to three halo atoms and aryl or heteroaryl is optionally substituted with one to two substituents independently selected from halo and cyano);R 2 is hydro, hydroxy, halo, cyano, (C 1-6)alkyl or (C 1-6)alkyloxy (wherein alkyl is optionally substituted with one to three halo atoms);R 3 is -C (O)R 7 (wherein R 7 is (C 1-6)alkyl, (C 3-6)cycloalkyl, di(C 1-4)alkylamino, N-(C 1-4)alkyl-N-(C 1-4)alkyloxyamino, (C 1-4)alkyl((C 1-4)alkyloxy)amino, pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl or piperazin-1-yl);R 4 is halo, hydroxy, cyano, (C 1-6)alkyl or (C 1-6)alkyloxy; andR 5 is (C 1-6)alkyl; and the pharmaceutically acceptable salts and N-oxides thereof.