178734-93-5Relevant articles and documents
Stereospecific synthesis of the anaesthetic levobupivacaine
Adger, Brian,Dyer, Ulrich,Hutton, Gordon,Woods, Martin
, p. 6399 - 6402 (2007/10/03)
Enantiomerically pure (S)-bupivacaine is synthesized from the chiral pool using cheap and readily available (S)-lysine. The key steps in this efficient synthesis include an oxidative de-amination and stereospecific ring closure to form the pipecolamide core structure.