1788-31-4

Basic information

• Product Name: DIBENZYL KETOXIME
• Synonyms: RARECHEM AQ A2 0065;LABOTEST-BB LT00847727;DIBENZYL KETOXIME;1,3-DIPHENYLPROPAN-2-ONE OXIME;1,3-Diphenylacetone oxime;2-Propanone, 1,3-diphenyl-, oxime;Dibenzyl ketoxime, 98+%;1,3-Diphenyl-2-propanone oxime
• CAS NO: 1788-31-4
• Molecular Formula: C₁₅H₁₅NO
• Molecular Weight: 225.29
• EINECS: 217-251-9
• Mol File: 1788-31-4.mol
• Article Data: 19

Chemical Properties

• Melting Point: 122-124°C
• Boiling Point: 407.8 °C at 760 mmHg
• Flash Point: 262.8 °C
• Appearance: White or pale yellow crystalline powder
• Density: 1.02 g/cm³
• Vapor Pressure: 2.2E-07mmHg at 25°C
• Refractive Index: 1.556
• Water Solubility: Insoluble in water.
• BRN: 1965977
• CAS DataBase Reference: DIBENZYL KETOXIME(CAS DataBase Reference)
• NIST Chemistry Reference: DIBENZYL KETOXIME(1788-31-4)
• EPA Substance Registry System: DIBENZYL KETOXIME(1788-31-4)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 1788-31-4(Hazardous Substances Data)

Usage

Description

Dibenzyl ketoxime is an organic compound that serves as a crucial intermediate in the synthesis of various chemical and pharmaceutical products. It is characterized by its unique structure and reactivity, making it a valuable component in the development of different applications.

Uses

Used in Chemical Synthesis:
Dibenzyl ketoxime is used as an intermediate for the preparation of cis-2-benzyl-3-phenylaziridine by reaction with lithium aluminum hydride. This reaction is significant in the synthesis of various organic compounds, contributing to the development of a wide range of chemical products.
Used in Pharmaceutical Industry:
Dibenzyl ketoxime is also utilized as a pharmaceutical intermediate, playing a vital role in the production of various medications. Its unique properties and reactivity make it an essential component in the development of new drugs and therapies, potentially benefiting the healthcare sector and patients in need.

InChI:InChI=1/C15H15NO/c17-16-15(11-13-7-3-1-4-8-13)12-14-9-5-2-6-10-14/h1-10,17H,11-12H2

Upstream product

• 102-04-5 1,3-Diphenylpropanone 
• 5470-11-1 hydroxylamine hydrochloride 
• 21192-56-3 bis(4-ethylphenyl)methanone 
• 64-17-5 ethanol 
• 7664-41-7 ammonia 

Downstream Products

• 4275-43-8 1-benzyl-2-phenylethylamine 
• 101102-91-4 2-chloro-2-nitroso-1,3-diphenylpropane 
• 288853-73-6 2-nitro-2-nitroso-1,3-diphenyl-propane 
• 19293-68-6 N-(1,3-Diphenyl-2-propyl)-hydroxylamin 
• 75498-70-3 1,3-Diphenyl-propan-2-one O-(1-benzyl-2-phenyl-ethylideneaminooxymethyl)-oxime 
• 7500-45-0 N-benzylphenylacetamide 
• 75413-12-6 2-methyl-4-benzyl-5-phenyl oxazole 
• 3647-71-0 N-benzyl-2-phenylethylamine 
• 102-04-5 1,3-Diphenylpropanone 
• 88054-96-0 N-vinyl-2-benzyl-3-phenylpyrrole 
• 103-82-2 phenylacetic acid 
• 140-29-4 phenylacetonitrile 
• 103-81-1 Benzeneacetamide 
• 113123-15-2 2,5-dibenzyl-3,4-diphenylpyrrole 

Relevant articles and documents

Synthesis and reactivity of platinum(II) triphenylphosphino complexes with aromatic aldoximes

trans-[Pt(μ-Cl)Cl(PPh3)]2 reacted with arylaldoximes in 1,2-dichloroethane to afford [PtCl2(PPh3){N(OH)[dbnd]CHAr}] (Ar = 3,4-dimethoxyphenyl, 1-naphthyl, 9-anthryl) where aldoxime ligands are N-coordinated to p

Copper-Catalyzed Aza-Sonogashira Cross-Coupling To Form Ynimines: Development and Application to the Synthesis of Heterocycles

Nitrogen-substituted alkynes, such as ynamines and ynamides, are versatile synthetic building blocks. Ynimines bearing additional nucleophilic and electrophilic centers relative to ynamines and ynamides are expected to have high synthetic potential. However, their chemical reactivity remains unexplored owing mainly to the lack of synthetic accessibility. We report herein a versatile copper-catalyzed synthesis of ynimines from readily available O-acetyl ketoximes and terminal alkynes. A wide range of O-acetyl ketoximes derived from diaryl ketones, aryl alkyl ketones and dialkyl ketones underwent cross-coupling with a diverse set of terminal alkynes to afford the ynimines in good to excellent yields. An unprecedented [5+1] heteroannulation reaction exploiting the reactivity of the ynimine generated in situ was subsequently developed for the synthesis of medicinally important heterocycles, including isoquinolines, azaindoles, azabenzofurans, azabenzothiophenes and carbolines.

Rhodium-catalysed synthesis of fused pyrimidine derivatives employing N-sulfonyl-1,2,3-triazoles as a 1-aza-[4C] synthon

A new synthetic application of N-sulfonyl-1,2,3-triazoles acting as a 1-aza-[4C] synthon via the 1,2-shift reaction of an α-imine rhodium carbene was developed for the synthesis of fused pyrimidine derivatives. The high reactivity of the strained three-me