17880-61-4

Basic information

• Product Name: Methyl 5-ethynylpyridine-2-carboxylate
• Synonyms: Methyl 5-ethynylpyridine-2-carboxylate;Methyl 5-ethynylpicolinate, 5-Ethynyl-2-(methoxycarbonyl)pyridine;Methyl 5-ethynylpicolinate
• CAS NO: 17880-61-4
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.15738
• Mol File: 17880-61-4.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 5-ethynylpyridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-ethynylpyridine-2-carboxylate(17880-61-4)
• EPA Substance Registry System: Methyl 5-ethynylpyridine-2-carboxylate(17880-61-4)

Safety Data

• Hazardous Substances Data: 17880-61-4(Hazardous Substances Data)

Usage

Description

Methyl 5-ethynylpyridine-2-carboxylate is a chemical compound with the molecular formula C9H7NO2. It is a derivative of pyridine with a methyl ester functional group and an ethynyl group attached to the 5th position of the pyridine ring.

Uses

Used in Organic Synthesis:
Methyl 5-ethynylpyridine-2-carboxylate is used as a building block in the preparation of various pharmaceuticals and agrochemicals. Its unique structure allows for the synthesis of a wide range of compounds with potential therapeutic and pesticidal properties.
Used in Chemical Research:
Methyl 5-ethynylpyridine-2-carboxylate is used as a reagent in chemical research. Its reactivity and functional groups make it a valuable tool for studying various chemical reactions and mechanisms.
Used in Material Science:
Methyl 5-ethynylpyridine-2-carboxylate has potential applications in the development of new materials and bioactive compounds. Its unique structure and properties can be utilized to create novel materials with specific characteristics and functions.
Used in Pharmaceutical Industry:
Methyl 5-ethynylpyridine-2-carboxylate is used as an intermediate in the synthesis of various pharmaceuticals. Its versatile structure allows for the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
Methyl 5-ethynylpyridine-2-carboxylate is used in the synthesis of agrochemicals, such as pesticides and herbicides. Its potential as a building block for these compounds can lead to the development of more effective and environmentally friendly products.
Safety Precautions:
Methyl 5-ethynylpyridine-2-carboxylate should be handled and stored according to proper safety protocols due to its potential health hazards and reactivity. Appropriate personal protective equipment and handling procedures should be followed to minimize risks associated with its use.

Upstream product

• 29682-15-3 methyl 5-bromopicolinate 
• 30766-11-1 5-bromoisonicotinic acid 

Downstream Products

• 1350553-45-5 methyl 5-((5-tert-butyl-2-(trifluoromethylsulfonyloxy)phenyl)ethynyl)picolinate 
• 1350553-48-8 methyl 5-((5-tert-butyl-2-((triisopropylsilyl)ethynyl)phenyl)ethynyl)picolinate 
• 1350553-51-3 methyl 5-((5-tert-butyl-2-ethynylphenyl)ethynyl)picolinate 
• 1350553-54-6 dimethyl 5,5'-(6,6'-(buta-1,3-diyne-1,4-diyl)bis(3-tert-butyl-6,1-phenylene)bis(ethyne-2,1-diyl))dipicolinate 
• 1350553-57-9 5,5'-(6,6'-(buta-1,3-diyne-1,4-diyl)bis(3-tert-butyl-6,1-phenylene)bis(ethyne-2,1-diyl))dipicolinic acid 

Relevant articles and documents

COMBINATION PRODUCT FOR THE TREATMENT OF CANCEROUS DISEASES

The present invention relates to a product for combination therapies useful for the treatment of cancer diseases. In particular, the invention relates to the combination of an anti-PD-Ll antibody and an MCT4 inhibitor of Formula (I). The therapeutic combination may be utilized for the use in treating a subject having a cancer disease that tests positive for PD-L1 and/or MCT4 expression.

Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3

Both cholinesterases (AChE and BChE) and kinases, such as GSK-3α/β, are associated with the pathology of Alzheimer's disease. Two scaffolds, targeting AChE (tacrine) and GSK-3α/β (valmerin) simultaneously, were assembled, using copper(I)-catalysed azide alkyne cycloaddition (CuAAC), to generate a new series of multifunctional ligands. A series of eight multi-target directed ligands (MTDLs) was synthesized and evaluated in vitro and in cell cultures. Molecular docking studies, together with the crystal structures of three MTDL/TcAChE complexes, with three tacrine-valmerin hybrids allowed designing an appropriate linker containing a 1,2,3-triazole moiety whose incorporation preserved, and even increased, the original inhibitory potencies of the two selected pharmacophores toward the two targets. Most of the new derivatives exhibited nanomolar affinity for both targets, and the most potent compound of the series displayed inhibitory potencies of 9.5 nM for human acetylcholinesterase (hAChE) and 7 nM for GSK-3α/β. These novel dual MTDLs may serve as suitable leads for further development, since, in the micromolar range, they exhibited low cytotoxicity on a panel of representative human cell lines including the human neuroblastoma cell line SH-SY5Y. Moreover, these tacrine-valmerin hybrids displayed a good ability to penetrate the blood-brain barrier (BBB) without interacting with efflux pumps such as P-gp.

ETHYNYLBENZENE DERIVATIVES

Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.