17894-25-6

Basic information

• Product Name: 2,5-DIMETHOXYBENZHYDRAZIDE
• Synonyms: 2,5-DIMETHOXYBENZOYL HYDRAZINE;2,5-DIMETHOXYBENZHYDRAZIDE;2,5-DIMETHOXYBENZOIC ACID HYDRAZIDE;2,5-Dimethoxybenzohydrazide
• CAS NO: 17894-25-6
• Molecular Formula: C₉H₁₂N₂O₃
• Molecular Weight: 196.2
• EINECS: 241-981-7
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 17894-25-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 89-91°C
• Appearance: /
• Density: 1.189
• Refractive Index: 1.544
• CAS DataBase Reference: 2,5-DIMETHOXYBENZHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHOXYBENZHYDRAZIDE(17894-25-6)
• EPA Substance Registry System: 2,5-DIMETHOXYBENZHYDRAZIDE(17894-25-6)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 17894-25-6(Hazardous Substances Data)

Usage

General Description

2,5-DIMETHOXYBENZHYDRAZIDE is a chemical compound with the molecular formula C10H14N2O3. It is a hydrazide derivative with two methoxy groups attached to the benzene ring. This chemical is commonly used as a pharmaceutical intermediate in the synthesis of various drugs and pharmaceutical products. 2,5-DIMETHOXYBENZHYDRAZIDE has been found to have potential antioxidant and anti-inflammatory properties, making it a subject of research for potential therapeutic applications. Additionally, it is also used in the manufacture of dyes and pigments. As with all chemical compounds, proper handling and precautions should be taken to ensure safety in use.

InChI:InChI=1/C9H12N2O3/c1-13-6-3-4-8(14-2)7(5-6)9(12)11-10/h3-5H,10H2,1-2H3,(H,11,12)

Upstream product

• 2785-98-0 2,5-dimethoxybenzoic acid 
• 2150-40-5 methyl 2,5-dimethoxybenzoate 

Downstream Products

• 1018856-48-8 C₁₀H₁₁N₂O₃S₂^(1-)*K⁽¹⁺⁾ 
• 1430092-75-3 C₁₆H₁₄N₂O₄S 
• 1242146-71-9 N-(2,5-bis-methoxybenzamido)-N'-phenylthiourea 

Relevant articles and documents

Isatin based Schiff bases as inhibitors of α-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies

Isatin base Schiff bases (1-20) were synthesized, characterized by 1H NMR and EI/MS and evaluated for α-glucosidase inhibitory potential. Out of these twenty (20) compounds only six analogs showed potent α-glucosidase inhibitory potential with IC50 value ranging in between 2.2 ± 0.25 and 83.5 ± 1.0 μM when compared with the standard acarbose (IC50 = 840 ± 1.73 μM). Among the series compound 2 having IC50 value (18.3 ± 0.56 μM), 9 (83.5 ± 1.0 μM), 11 (3.3 ± 0.25 μM), 12 (2.2 ± 0.25 μM), 14 (11.8 ± 0.15 μM), and 20 (3.0 ± 0.15 μM) showed excellent inhibitory potential many fold better than the standard acarbose. The binding interactions of these active analogs were confirmed through molecular docking.

PHOSPHODIESTERASE INHIBITORS

The invention relates to compounds of formula I useful for inhibiting phosphodiesterase-4

Identification of a potent new chemotype for the selective inhibition of PDE4

A series of substituted 3,6-diphenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines were prepared and analyzed as inhibitors of phosphodiesterase 4 (PDE4). Synthesis, structure-activity relationships, and the selectivity of a highly potent analogue against related phosphodiesterase isoforms are presented.