178993-28-7Relevant articles and documents
AMINO PYRIMIDINE COMPOUND FOR INHIBITING PROTEIN TYROSINE KINASE ACTIVITY
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Paragraph 0446; 0448, (2019/06/07)
An amino pyrimidine compound for inhibiting protein tyrosine kinase activity, a pharmaceutical composition thereof, preparation therefor, and an application thereof. Specifically, an amino pyrimidine compound represented by formula (I), R1, R2, L, Y, R6, W, A, m, and n being defined in the specification, and a pharmaceutically acceptable salt, a stereoisomer, a solvent compound, a hydrate, a polymorphism, a prodrug, or an isotope variant thereof. The compound can be used for treating and/or preventing protein tyrosine kinase-related diseases such as cell proliferative diseases, cancers, and immune diseases.
An arylamino pyrimidine compound and crystals of salts of the compound
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Paragraph 0118; 0120, (2017/09/01)
The invention provides an arylamino pyrimidine compound and crystals of salts thereof, belongs to the technical fields of medicines and chemical engineering, and particularly relates to N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-ethyoxyl-5-(4-(1-methy
Pyrimidine or triazine derivative, and preparation method and use thereof
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Paragraph 0157; 0159, (2016/10/08)
The invention relates to an arylaminopyrimidine or triazine derivative, and a preparation method, a medicinal composition and a use thereof, and concretely relates to a compound represented by formula I, or a pharmaceutically acceptable salt or a solvate thereof. In the formula I, R1 to R7, X and Y are defined in the description and claims. The invention also relates to a preparation method of the compound of formula I, the medicinal composition containing the compound, and the pharmacy use of the compound and the medicinal composition. The compound of formula I is an effective tyrosine kinase irreversible inhibitor, and especially has a strong inhibition effect on EGFR-T790M drug-resistant tumors.