179187-31-6Relevant articles and documents
Synthesis of Diverse Macrocyclic Peptidomimetics Utilizing Ring-Closing Metathesis and Solid-Phase Synthesis
Barrett, Anthony G. M.,Hennessy, Alan J.,Le Vezouet, Ronan,Procopiou, Panayiotis A.,Seale, Peter W.,Stefaniak, Stefan,Upton, Richard J.,White, Andrew J. P.,Williams, David J.
, p. 1028 - 1037 (2007/10/03)
The synthesis of a range of highly functionalized peptidomimetic macrocycles has been accomplished using ring-closing metathesis and enyne tandem cross-metathesis-ring-closing metathesis reactions. This approach gives access to rigidified macrocycles mode
LTB4 antagonists and radiopharmaceuticals for imaging infection and inflammation
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, (2008/06/13)
The present invention provides novel radiopharmaceutials useful for the diagnosis of infection and inflammation, reagents and kits useful for preparing the radiopharmaceuticals, methods of imaging sites of infection and/or inflammation in a patient, and methods of diagnosing diseases associated with infection or inflammation in patients in need of such diagnosis. The radiopharmaceuticals bind in vivo to the leukotriene B4 (LTB4) receptor on the surface of leukocytes which accumulate at the site of infection and inflammation. The reagents provided by this invention are also useful for the treatment of diseases associated with infection and inflammation.
Radiopharmaceuticals for imaging infection and inflammation
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, (2008/06/13)
The present invention provides novel radiopharmaceuticals useful for the diagnosis of infection and inflammation, reagents and kits useful for preparing the radiopharmaceuticals, methods of imaging sites of infection and/or inflammation in a patient, and
