17921-64-1

Basic information

• Product Name: 3β-Hydroxy-androsta-5,15-dien-17-one Acetate
• Synonyms: 3β-Acetoxy-5,15-androstadien-17-one;3β-Hydroxy-androsta-5,15-dien-17-one Acetate;3β-O-Acetyl-androsta-5,15-dien-17-one
• CAS NO: 17921-64-1
• Molecular Formula: C₂₁H₂₈O₃
• Molecular Weight: 328.44522
• Mol File: 17921-64-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 179-181 °C(Solv: hexane (110-54-3))
• Boiling Point: 441.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 3β-Hydroxy-androsta-5,15-dien-17-one Acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 3β-Hydroxy-androsta-5,15-dien-17-one Acetate(17921-64-1)
• EPA Substance Registry System: 3β-Hydroxy-androsta-5,15-dien-17-one Acetate(17921-64-1)

Safety Data

• Hazardous Substances Data: 17921-64-1(Hazardous Substances Data)

Usage

Description

3β-Hydroxy-androsta-5,15-dien-17-one Acetate is a white solid steroidal compound that serves as a key intermediate in the synthesis of various pharmaceuticals, particularly in the preparation of Drospirenone, a progestin hormone used in contraceptives and hormone replacement therapy.

Uses

Used in Pharmaceutical Industry:
3β-Hydroxy-androsta-5,15-dien-17-one Acetate is used as a chemical intermediate for the synthesis of Drospirenone, a progestin hormone. It plays a crucial role in the development of contraceptive pills and hormone replacement therapies, providing effective regulation of hormonal balance and menstrual cycles.
Additionally, due to its steroidal structure, 3β-Hydroxy-androsta-5,15-dien-17-one Acetate may also be utilized in the synthesis of other steroidal drugs, contributing to the treatment of various medical conditions related to hormonal imbalances and other steroid-responsive disorders.

Upstream product

• 853-23-6 prasterone acetate 
• 108-24-7 acetic anhydride 
• 17921-62-9 17,17-ethylenedioxy-3β-hydroxyandrosta-5,15-diene 
• 17921-63-0 3β-hydroxy-androst-5,15-dien-17-one 

Downstream Products

• 1382472-04-9 (3S,10R,13S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13-decahydro-1H-cyclopenta[a]phenanthren-3-yl 2-(tert-butyl)benzoate 
• 1382472-00-5 (3S,10R,13S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13-decahydro-1H-cyclopenta[a]phenanthren-3-yl 2,6-dimethylbenzoate 
• 67372-65-0 3β-hydorxy-15β,16β-methylene androst-5-ene-17-one 

Relevant articles and documents

The preparation and reactions of some 17 alpha-hydroxy-15-pregnen-20-ones.

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Palladium(II)-Catalyzed Dehydroboration via Generation of Boron Enolates

The PdII-catalyzed dehydroboration of boron enolates generated from ketones and 9-iodo-9-borabicyclo[3.3.1]nonane was achieved, providing a synthetically versatile protocol from ketones to α,β-unsaturated ketones. The PdIIcompound employed in this reaction worked catalytically in the presence of Cu(OAc)2. The high trans-selectivity of the olefinic moiety was observed. Aryl halide moieties (-Br and -Cl) remained intact for this reaction in spite of the presence of a Pd species. An ester substrate could also be applied when a stoichiometric amount of PdIIwas used. The crossover reactions using boron and silyl enolates revealed that the oxidation reaction is much faster than the Saegusa-Ito reaction.

CYP11B, CYP17, AND/OR CYP21 INHIBITORS

Provided herein are inhibitors of CYP11B, CYP17, and/or CYP21 enzymes of Formula (Z), (IX), (X), (XI), (XII), (XIII), (XIV), (XV), (XVI), or (XVII). Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions. Formula (Z)