179337-57-6 Usage
Description
3-Azetidinethiol, 1-(4,5-dihydro-2-thiazolyl)-, monohydrochloride is an organic compound with the chemical structure featuring a thiazolyl group attached to an azetidinethiol ring. It is a derivative of azetidinethiol and is commonly used in the synthesis of various pharmaceutical compounds due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
3-Azetidinethiol, 1-(4,5-dihydro-2-thiazolyl)-, monohydrochloride is used as a key reagent in the synthesis of Tebipenem Tetrahydrate (T012840), an antibiotic with potent bactericidal activity. 3-Azetidinethiol, 1-(4,5-dihydro-2-thiazolyl)-, monohydrochloride is particularly effective against β-lactamase-nonproducing, ampicillin-resistant bacterial isolates, making it a valuable addition to the arsenal of antibiotics used to combat drug-resistant infections.
Additionally, the compound serves as a precursor to the active metabolite of Tebipenem Pivoxil (T012900), further highlighting its importance in the development of new and effective antimicrobial agents to address the growing challenge of antibiotic resistance.
Check Digit Verification of cas no
The CAS Registry Mumber 179337-57-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,9,3,3 and 7 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 179337-57:
(8*1)+(7*7)+(6*9)+(5*3)+(4*3)+(3*7)+(2*5)+(1*7)=176
176 % 10 = 6
So 179337-57-6 is a valid CAS Registry Number.
179337-57-6Relevant articles and documents
An efficient method for the synthesis of 3-mercapto-1-(1,3-thiazolin-2-YL)Azetidine useful for the pendant moiety of oral carbapenem, L-084
Isoda, Takeshi,Tamai, Satoshi,Kumagai, Toshio,Nagao, Yoshimitsu
, p. 1821 - 1824 (2006)
An efficient method for the synthesis of 3-mercapto-1-(1,3-thiazolin-2-yl)azetidine (1) is described. This thiol synthesis was achieved in 3 steps from readily available 3-methanesulfonyloxyazetidine via key intermediates, Bunte salts (3 and 5). The final step was enabled to proceed under mild conditions using the benzylthiol-mediated cleavage of the S-S bond in the Bunte salt (3).{A figure is presented}.
