179400-16-9

Basic information

• Product Name: 5-METHYL-PYRIDINE-2-SULFONYL CHLORIDE
• Synonyms: 5-METHYL-PYRIDINE-2-SULFONYL CHLORIDE
• CAS NO: 179400-16-9
• Molecular Formula: C₆H₆ClNO₂S
• Molecular Weight: 191.64
• Mol File: 179400-16-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-METHYL-PYRIDINE-2-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-PYRIDINE-2-SULFONYL CHLORIDE(179400-16-9)
• EPA Substance Registry System: 5-METHYL-PYRIDINE-2-SULFONYL CHLORIDE(179400-16-9)

Safety Data

• Hazardous Substances Data: 179400-16-9(Hazardous Substances Data)

Usage

General Description

5-Methyl-pyridine-2-sulfonyl chloride is a chemical compound with the molecular formula C6H6ClNO2S. It is an organosulfur compound that is utilized as a reagent in various chemical processes, particularly in the synthesis of pharmaceuticals and agrochemicals. 5-METHYL-PYRIDINE-2-SULFONYL CHLORIDE is commonly used as an intermediate in the production of other organic compounds, including dyes, pigments, and pharmaceutical ingredients. It is a reactive compound that is sensitive to moisture and air, and should be handled with caution in a controlled laboratory environment.

Upstream product

• 18368-64-4 2-chloro-5-methylpyridine 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 18368-58-6 2-mercapto-5-methylpyridine 

Downstream Products

• 251101-37-8 4-(5-methylpyridin-2-yl)morpholine 
• 51933-81-4 5-methyl-2-phenoxypyridine 
• 179400-51-2 5-methyl-pyridine-2-sulphonic acid 6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2,2'-bipyrimidin-4-ylamide 
• 179400-53-4 5-methyl-pyridine-2-sulphonic acid 6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-ylamide 

Relevant articles and documents

Transition-Metal-Catalyzed Transformation of Sulfonates via S-O Bond Cleavage: Synthesis of Alkyl Aryl Ether and Diaryl Ether

The catalytic conversion of sulfonates, a versatile class of pharmaceutical intermediates, is usually based on C-O bond cleavage. In this paper, however, we discover a rare transformation of sulfonates via S-O bond cleavage catalyzed by transition metal, through which alkyl sulfonates could undergo an intramolecular desulfitative C-O coupling to form aryl alkyl ethers in the presence of a nickel catalyst. Meanwhile, aryl sulfonates perform similarly to give diaryl ethers catalyzed by a palladium complex. This transformation could tolerate a wide range of functionalities. Controlled experiments reveal that the 2-pyridyl group is necessary to promote the reaction as designed. Crossover experiments proved that this transformation might proceed partly in an intermolecular pathway.

SULFONYLAMINO-ACETIC ACID DERIVATIVES

The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.