179420-68-9

Basic information

• Product Name: 2H-Pyran-4-methanol, 4-[3-fluoro-5-(phenylmethoxy)phenyl]tetrahydro-
• CAS NO: 179420-68-9
• Molecular Formula: C19H21FO3
• Molecular Weight: 316.372
• Mol File: 179420-68-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2H-Pyran-4-methanol, 4-[3-fluoro-5-(phenylmethoxy)phenyl]tetrahydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran-4-methanol, 4-[3-fluoro-5-(phenylmethoxy)phenyl]tetrahydro-(179420-68-9)
• EPA Substance Registry System: 2H-Pyran-4-methanol, 4-[3-fluoro-5-(phenylmethoxy)phenyl]tetrahydro-(179420-68-9)

Safety Data

• Hazardous Substances Data: 179420-68-9(Hazardous Substances Data)

Upstream product

• 179420-66-7 ethyl 4-(5-benzyloxy-3-fluorophenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate 
• 179420-64-5 diethyl 5-benzyloxy-3-fluorophenylmalonate 
• 179420-65-6 ethyl 3-benzyloxy-5-fluorophenylacetate 
• 130722-44-0 5-benzyloxy-3-fluorophenyl bromide 

Downstream Products

• 179420-69-0 4-formyl-4-[5-(benzyloxy)-3-fluorophenyl]-3,4,5,6-tetrahydro-2H-pyran 
• 179420-71-4 4-(1-hydroxyethyl)-4-(3-fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran 
• 179420-72-5 4-Acetyl-4-(3-fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran 
• 179420-70-3 4-(1-hydroxyethyl)-4-(5-benzyloxy-3-fluorophenyl)-3,4,5,6-tetrahydro-2H-pyran 

Relevant articles and documents

4-[5-Fluoro-3-[4-(2-methyl-1H-imidazol-1-yl)benzyloxy]phenyl]-3,4,5, 6-tetrahydro-2H-pyran-4-carboxamide, an Orally Active Inhibitor of 5-Lipoxygenase with Improved Pharmacokinetic and Toxicology Characteristics

Described herein are structure- activity relationships (SARs) of 4-[5-fluoro-3-[4-(2-methyl-1H-imidazol-1-yl)benzyloxy]-phenyl]-4-methoxy-3,4,5, 6-tetrahydro-2H-pyran (1, CJ-12,918), an imidazole 5-lipoxygenase (5-LO) inhibitor. When 1 was tested in precl