179473-63-3Relevant articles and documents
Oxime ether derivative and preparation method and application thereof
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Paragraph 0084; 0086, (2018/08/03)
The invention discloses oxime ether derivative and a preparation method and application thereof. The oxime ether derivative is shown as any one of 1) to 6), wherein the 1) is 5-bromine-1-naphthalene formaldehyde oxime ether, the 2) is 5-methoxy-1-naphthalene formaldehyde oxime ether, the 3) is 5-phenyl-1-naphthalene formaldehyde oxime ether, the 4) is 5-p-methoxyphenyl-1-naphthalene formaldehyde oxime ether, the 5) is 5-p-ethoxyphenyl-1-naphthalene formaldehyde oxime ether, and the 6) is 3-5-ethyl(E)-1-naphthalene formaldehyde oxime ether. According to the oxime ether derivative, 1-naphthoic acid is utilized as a raw material; the oxime ether derivative is synthesized by coupling reaction of Suzuki reaction, Heck reaction and the like, acylation reaction and oximation reaction. The compound disclosed by the invention has good antineoplastic activity and has a very good prospect in medicinal development.