179481-94-8

Basic information

• Product Name: 1,6-Dihydro-5-methoxycarbonyl-2-methoxy-4-methyl-6-(4-nitro-phenyl)-pyrimidine
• CAS NO: 179481-94-8
• Molecular Weight: 305.29
• Mol File: 179481-94-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,6-Dihydro-5-methoxycarbonyl-2-methoxy-4-methyl-6-(4-nitro-phenyl)-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,6-Dihydro-5-methoxycarbonyl-2-methoxy-4-methyl-6-(4-nitro-phenyl)-pyrimidine(179481-94-8)
• EPA Substance Registry System: 1,6-Dihydro-5-methoxycarbonyl-2-methoxy-4-methyl-6-(4-nitro-phenyl)-pyrimidine(179481-94-8)

Safety Data

• Hazardous Substances Data: 179481-94-8(Hazardous Substances Data)

Upstream product

• 29427-58-5 O-methylisourea hemisulfate 
• 40641-47-2 methyl 2-{(4-nitrophenyl)methylene}-3-oxobutyrate 

Downstream Products

• 179481-95-9 1,6-dihydro-2-methoxy-5-methoxycarbonyl-4-methyl-6-(4-nitrophenyl)-1-[(4-nitrophenyloxy)carbonyl]pyrimidine 
• 179480-93-4 1,6-dihydro-1-{N-[3-(4,4-diphenylpiperidin-1-yl)propyl]carboxamido}-2-methoxy-5-methoxycarbonyl-4-methyl-6-(4-nitrophenyl)pyrimidine 
• 251930-30-0 2-methoxy-1-[3-(4-methoxycarbonyl-4-phenyl-piperidin-1-yl)-propylcarbamoyl]-4-methyl-6-(4-nitro-phenyl)-1,6-dihydro-pyrimidine-5-carboxylic acid methyl ester 
• 263358-30-1 4-(4-nitro-phenyl)-2,5-dioxo-1,2,5,7-tetrahydro-4H-furo[3,4-d]pyrimidine-3-carboxylic acid 4-nitro-phenyl ester 

Relevant articles and documents

5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines

This invention is directed to dihydropyrimidine compounds of the following formula: which are selective antagonists for human α1Creceptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotence, cardiac arrhythmia and for the treatment of any disease where antagonism of the α1Creceptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

5-(HETEROCYCLIC ALKYL)-6-ARYL-DIHYDROPYRIMIDINES

This invention is directed to dihydropyrimidine compounds which are selective antagonists for human α 1C receptors and which have the structure: STR1 wherein A is aryl; R 1, R 2 and R. sub.3 are alkyl or heteroalkyl; R 4 is heterocyclic alkyl; and X is S, O or NR 3. This invention also relates to use of these compounds for the treatment of benign prostatic hyperplasia and other diseases where antagonism of the human α 1C receptor is useful. The invention further provides pharmaceutical compositions comprising a therapeutically effective amount of such a compound and a pharmaceutically acceptable carrier.