179691-31-7

Basic information

• Product Name: Carbonochloridic acid, 2-(2-nitrophenyl)propyl ester
• Synonyms: NPPOCCl;2-(2-nitrophenyl)propoxycarbonyl chloride;nppoc-Cl;[2-(2-nitrophenyl)propoxy]carbonyl chloride;(3'-nitrophenylpropyloxycarbonyl) chloride;2-(2-nitrophenyl)propyloxycarbonyl chloride
• CAS NO: 179691-31-7
• Molecular Formula: C10H10ClNO4
• Molecular Weight: 243.647
• Mol File: 179691-31-7.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Carbonochloridic acid, 2-(2-nitrophenyl)propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbonochloridic acid, 2-(2-nitrophenyl)propyl ester(179691-31-7)
• EPA Substance Registry System: Carbonochloridic acid, 2-(2-nitrophenyl)propyl ester(179691-31-7)

Safety Data

• Hazardous Substances Data: 179691-31-7(Hazardous Substances Data)

Upstream product

• 64987-77-5 2-(2-nitrophenyl)propanol 
• 121-44-8 triethylamine 
• 503-38-8 trichloromethyl chloroformate 
• 702642-17-9 1-bromo-2-ethyl-3-nitrobenzene 
• 702642-25-9 4-ethyl-3,5-dinitrobenzeneamine 
• 90007-09-3 2-ethyl-3-nitrobenzeneamine 
• 13985-56-3 2-ethyl-1,3-dinitrobenzene 
• 13985-60-9 2-ethyl-1,3,5-trinitrobenzene 
• 75-44-5 phosgene 
• 702642-19-1 2-ethyl-1-iodo-3-nitrobenzene 
• 612-22-6 2-nitro(ethylbenzene) 

Downstream Products

• 869082-21-3 2-(2-nitrophenyl)propoxycarbonyl hydrazine 
• 1293390-68-7 N₄-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)cytidine 5'-[2-(2-nitrophenyl)propyl carbonate] 
• 1293390-75-6 N₄-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)cytidine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) 5'-[2-(2-nitrophenyl)propyl carbonate] 
• 1293390-69-8 N₆-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)adenosine 5'-[2-(2-nitrophenyl)propyl carbonate] 
• 1293390-70-1 N₂-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O₆-[2-(4.nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 5'-[2-(2-nitrophenyl)propyl carbonate] 
• 1293390-64-3 2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)uridine 5'-[2-(2-nitrophenyl)propyl carbonate] 

Relevant articles and documents

A Singular System with Precise Dosing and Spatiotemporal Control of CRISPR-Cas9

Several genome engineering applications of CRISPR-Cas9, an RNA-guided DNA endonuclease, require precision control of Cas9 activity over dosage, timing, and targeted site in an organism. While some control of Cas9 activity over dose and time have been achieved using small molecules, and spatial control using light, no singular system with control over all the three attributes exists. Furthermore, the reported small-molecule systems lack wide dynamic range, have background activity in the absence of the small-molecule controller, and are not biologically inert, while the optogenetic systems require prolonged exposure to high-intensity light. We previously reported a small-molecule-controlled Cas9 system with some dosage and temporal control. By photocaging this Cas9 activator to render it biologically inert and photoactivatable, and employing next-generation protein engineering approaches, we have built a system with a wide dynamic range, low background, and fast photoactivation using a low-intensity light while rendering the small-molecule activator biologically inert. We anticipate these precision controls will propel the development of practical applications of Cas9.

METHODS OF SYNTHESIZING A POLYNUCLEOTIDE ARRAY USING PHOTOACTIVATED AGENTS

Described herein are methods for the synthesis of DNA polynucleotides and polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of DNA microarrays.

Photolabile peptide nucleic acid monomers: Synthesis and photodeprotection

The photolabile 2-(2-nitrophenyl)propyloxy carbonyl (NPPOC) group has been introduced as an amino protecting group for peptide nucleic acids (PNA) to be used as building blocks in photolithographic solid-phase PNA synthesis. NPPOC-protected PNA derivative