17977-76-3 Usage
Description
2-chloro-N-(4-chloro-2-((hydroxyiMino)(phenyl)Methyl)phenyl)acetaMide is a chemical compound with the molecular formula C15H11Cl2N3O2. It is a derivative of acetamide, which is a class of organic compounds that contain an amide functional group. 2-chloro-N-(4-chloro-2-((hydroxyiMino)(phenyl)Methyl)phenyl)acetaMide is characterized by the presence of two chlorine atoms, a hydroxyimino group, and a phenylmethyl group attached to the phenyl ring. Its unique structure and properties make it a versatile molecule with potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
2-chloro-N-(4-chloro-2-((hydroxyiMino)(phenyl)Methyl)phenyl)acetaMide is used as an intermediate in the synthesis of quinazoline (Q670100) and 1,4-diazepine derivatives. These compounds are of significant interest in the pharmaceutical industry due to their diverse range of biological activities, including anticancer, antiviral, and anti-inflammatory properties. The development of new and effective drugs based on these scaffolds can potentially lead to the discovery of novel therapeutic agents for the treatment of various diseases.
Used in Antioxidant Activity:
2-chloro-N-(4-chloro-2-((hydroxyiMino)(phenyl)Methyl)phenyl)acetaMide also exhibits antioxidant activity, which is an important property in the field of health and nutrition. Antioxidants are compounds that can neutralize free radicals, which are unstable molecules that can cause damage to cells and contribute to the aging process and the development of various diseases. By incorporating this compound into food products, cosmetics, or pharmaceutical formulations, it can help protect against oxidative stress and promote overall health and well-being.
Check Digit Verification of cas no
The CAS Registry Mumber 17977-76-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,9,7 and 7 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 17977-76:
(7*1)+(6*7)+(5*9)+(4*7)+(3*7)+(2*7)+(1*6)=163
163 % 10 = 3
So 17977-76-3 is a valid CAS Registry Number.
17977-76-3Relevant articles and documents
Synthesis of substituted 3-anilino-5-phenyl-1,3-dihydro-2H-1,4- benzodiazepine-2-ones and their evaluation as cholecystokinin-ligands
Offel, Michael,Lattmann, Pornthip,Singh, Harjit,Billington,Bunprakob, Yodchai,Sattayasai, Jintana,Lattmann, Eric
, p. 163 - 173 (2007/10/03)
3-Amino-1,4-benzodiazepines as well as chemically related diverse amines were prepared from oxazepam and subsequently screened on the cholecystokinin receptor in a radiolabel binding assay. Oxazepam 2 was activated via its 3-chloro-1,4-benzodiazepine intermediate 3 and was reacted with a large series of aliphatic and aromatic amines. The substituted 3-anilino-1,4-benzodiazepine structure was identified as lead structure in a diverse series of 3-amino-1,4-benzodiazepines 4-38 and the full SAR (structure-activity relationship) optimisation provided 3-anilinobenzodiazepines 16-38 with CCK 1 receptor selectivity to CCK2. The compounds 18, 24, 28 and 33 have shown affinities at the CCK1 receptor of 11, 10, 11 and 9 nM, respectively. These equipotent CCK1 ligands were fully evaluated in behaviour pharmacological essays. An antidepressant effect was identified in the tail suspension- and the Porsolt swimming-test. The ED50 values for 24 and 28 were determined in these assays as 0.46 and 0.49 mg/kg. The mixed antagonist 37 showed in addition to the antidepressant effects anxiolytic properties.
