1798-83-0

Basic information

• Product Name: 1-(4-CHLOROPHENYL)-3-(DIMETHYLAMINO)PROPAN-1-ONE HYDROCHLORIDE
• Synonyms: 1-(4-chlorophenyl)-3-(dimethylamino)-1-propanonehydrochloride;1-(4-chlorophenyl)-3-(dimethylamino)-1-propanonhydrochloride;1-(4-CHLOROPHENYL)-3-(DIMETHYLAMINO)PROPAN-1-ONE HYDROCHLORIDE;3-(4-CHLOROPHENYL)-N,N-DIMETHYL-3-OXO-1-PROPANAMINIUM CHLORIDE;BUTTPARK 75\04-47;1-(4-Chlorophenyl)-3-(dimethylamino)propan-1-oneHCl;4''-CHLORO-3-(N,N-DIMETHYLAMINO)PROPIOPHENONE HYDROCHLORIDE
• CAS NO: 1798-83-0
• Molecular Formula: C₁₁H₁₄ClNO*ClH
• Molecular Weight: 248.15
• Mol File: 1798-83-0.mol
• Article Data: 17

Chemical Properties

• Melting Point: 174-175 °C
• Boiling Point: 310°Cat760mmHg
• Flash Point: 141.3°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.000615mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly, Heated)
• Stability: Unstable in Aqueous Solution
• CAS DataBase Reference: 1-(4-CHLOROPHENYL)-3-(DIMETHYLAMINO)PROPAN-1-ONE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLOROPHENYL)-3-(DIMETHYLAMINO)PROPAN-1-ONE HYDROCHLORIDE(1798-83-0)
• EPA Substance Registry System: 1-(4-CHLOROPHENYL)-3-(DIMETHYLAMINO)PROPAN-1-ONE HYDROCHLORIDE(1798-83-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 1798-83-0(Hazardous Substances Data)

Usage

General Description

1-(4-Chlorophenyl)-3-(dimethylamino)propan-1-one hydrochloride, also known as 4-CPVP, is a synthetic stimulant drug with psychoactive effects. It belongs to the cathinone class of chemicals and is structurally related to the widely known synthetic cathinone, alpha-pyrrolidinopentiophenone (α-PVP). 4-CPVP is reported to have strong effects on the central nervous system, including increased alertness, hyperactivity, and elevated mood. It is also known to have addictive properties and potential health risks with chronic use, including cardiovascular and psychological disturbances. Due to its potential for abuse, 4-CPVP is classified as a controlled substance in many countries, and its recreational use is prohibited in most jurisdictions.

InChI:InChI=1/C11H14ClNO/c1-13(2)8-7-11(14)9-3-5-10(12)6-4-9/h3-6H,7-8H2,1-2H3

Upstream product

• 50-00-0 formaldehyd 
• 99-91-2 para-chloroacetophenone 
• 124-40-3 dimethyl amine 
• 30354-18-8 N,N-dimethyl(methylene)ammonium chloride 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 81234-31-3 1-(4-Chloro-phenyl)-3-[1,2,4]triazol-1-yl-propan-1-one 
• 113193-72-9 1-(4-chlorophenyl)-3-(1H-imidazol-1-yl)-1-propanone 
• 23934-66-9 1-(4-Chlor-benzoyl)-2-benzhydrylamino-aethan 
• 1798-84-1 1-chloro-4-cyclopropylbenzene 
• 19578-13-3 1-(p-Chlorophenyl)-3-(4'-morpholinyl)-1-propanone 
• 32594-52-8 β-(piperidino)-p-chloropropiophenone 
• 30412-07-8 1-(4-chlorophenyl)-3-(morpholin-1-yl)propane-1-one hydrochloride 
• 1607450-28-1 2-(benzylamino)-6-(4-chlorophenyl)-8,9-dihydro-3-methyl-3Hpyrimido[4,5-b][1,4]diazepin-4(7H)-one 
• 1607450-34-9 2-(benzylamino)-6-(4-chlorophenyl)-8,9-dihydro-3H-pyrimido[4,5-b][1,4]diazepin-4(7H)-one 
• 1037492-18-4 3-(benzyl(methyl)amino)-1-(4-chlorophenyl)propan-1-ol 
• 1092851-28-9 1-(4-chlorophenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride 
• 1440859-11-9 ±-1-(4-chlorophenyl)-3-(1H-imidazol-1-yl)-1-propanol hydrochloride 
• 1024592-16-2 C₂₂H₁₆ClNO₂ 

Relevant articles and documents

Synthesis of some new 6-aryl-2-(3-oxo-1, 4-benzoxazin-6-yl)pyridines

A series of some new 6-aryl-2-(3-oxo-1,4-benzoxazin-6-yl)pyridines (3a-g) have been prepared.

Synthesis of 4-(3-oxo-3-phenylpropyl)morpholin-4-ium chloride analogues and their inhibitory activities of nitric oxide production in lipopolysaccharide-induced BV2 cells

Based on our previous report that 3-morpholino-1-phenylpropan-1-one 2, one of the fluoxetine's simplified morpholino analogue, inhibited nitric oxide (NO) production, in this paper, various substituted benzene analogues with morpholine hydrochloride of 2 were synthesized and their inhibitory effects on NO production in lipopolysaccharide (LPS)-induced BV2 cells were tested. Among the synthesized compounds, 2-trifluoromethyl analogue 16n (IC50 = 8.6 μM) showed a significantly higher inhibitory activity than that of the parent compound 2a (IC50 > 50 μM) and suppressed NO production dose-dependently without cytotoxicity. Compound 16n also inhibited iNOS expression in LPS-induced BV2 cells at 2, 10 and 20 μM concentrations. These results suggest that compound 16n inhibited NO production by suppressing the expression of iNOS and can be used as a lead structure for developing new inhibitor of NO production.

ARALKYL DIAMINE DERIVATIVES AND USES THEREOF AS ANTIDEPRESSANTS

Aralkyl diamine derivative of the following formula, pharmaceutically acceptable salts or uses thereof as antidepressants. The derivatives have triplex inhibiting activities of the reuptake of 5-HT, dopamine and noradrenalin, which can be administered to the patients in need of such treatment in the form of compositions orally or injectedly et al.