17983-62-9Relevant articles and documents
Development of novel silicon-containing inverse agonists of retinoic acid receptor-related orphan receptors
Toyama, Hirozumi,Nakamura, Masaharu,Nakamura, Masahiko,Matsumoto, Yotaro,Nakagomi, Madoka,Hashimoto, Yuichi
, p. 1948 - 1959 (2014/03/21)
Retinoic acid receptor (RAR)-related orphan receptors (RORs) regulate a variety of physiological processes, including hepatic gluconeogenesis, lipid metabolism, circadian rhythm and immune function. The RAR agonist: all-trans retinoic acid was reported to be an RORβ inverse agonist, but no information is available regarding ROR activity of its synthetic analogue Am580. Therefore, we screened Am580 and some related tetramethyltetrahydronaphthalene derivatives and carried out structural development studies, including substitution of carbon atoms with silicon, with the aim of creating a potent ROR transcriptional inhibitor. The phenyl amide disila compound 22 showed the most potent ROR-inhibitory activity among the compounds examined. Its activity towards RORα, RORβ and RORγ was increased compared to that of Am580. The IC50 values for RORα, RORβ and RORγ are 1.3, >10 and 4.5 μM, respectively.
Heterocyclic dihydrazole compounds and their use for controlling fungal plant diseases
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, (2008/06/13)
PCT No. PCT/US96/06533 Sec. 371 Date Nov. 13, 1997 Sec. 102(e) Date Nov. 13, 1997 PCT Filed May 8, 1996 PCT Pub. No. WO96/36633 PCT Pub. Date Nov. 21, 1996Compounds of Formula I, and their N-oxides and agriculturally suitable salts, are disclosed which ar
Synthese d'aryl- et heteroarylsilanes par scission de l'hexamethyldisilane
Babin, P.,Bennetau, B.,Theurig, M.,Dunogues, J.
, p. 135 - 138 (2007/10/02)
In the presence of hexamethylphosphormaide and a catalytic quantity of tetrakis(triphenylphosphine)palladium, hexamethyldisilane reacts with various functional aryl bromides to give the corresponding arylsilanes in satisfactory yields.The reaction has bee
