1798310-55-0 Usage
Description
N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide is a complex organic compound with a unique chemical structure. It is characterized by the presence of a 2,5-dichlorophenyl group, a furan-2-yl group, and a 2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide moiety. N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide has potential applications in various fields due to its specific chemical properties and interactions.
Uses
Used in Pharmaceutical Industry:
N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide is used as a selective and moderately potent positive allosteric modular (PAM)-agonist for the FFA3 receptor. Its application is based on its ability to inhibit short chain fatty acids in a noncompetitive manner as a negative allosteric modulator in human and rodent cells. This makes it a promising candidate for the development of new therapeutic strategies targeting the FFA3 receptor, which is involved in various physiological processes and diseases.
Used in Chemical Research:
Due to its unique chemical structure, N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide can be used as a starting material or intermediate in the synthesis of other complex organic compounds. It may also serve as a model compound for studying the properties and reactivity of similar structures in chemical research.
Used in Drug Design and Development:
The compound's specific interactions with biological targets, such as the FFA3 receptor, make it a valuable tool in drug design and development. Researchers can use this compound to gain insights into the structure-activity relationships of other potential PAM-agonists or antagonists for the FFA3 receptor, leading to the development of more effective and selective therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 1798310-55-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,7,9,8,3,1 and 0 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1798310-55:
(9*1)+(8*7)+(7*9)+(6*8)+(5*3)+(4*1)+(3*0)+(2*5)+(1*5)=210
210 % 10 = 0
So 1798310-55-0 is a valid CAS Registry Number.
1798310-55-0Relevant articles and documents
Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators
Ulven, Elisabeth Rexen,Quon, Tezz,Sergeev, Eugenia,Barki, Natasja,Brvar, Matjaz,Hudson, Brian D.,Dutta, Palash,Hansen, Anders H?jgaard,Bielefeldt, Line O.,Tobin, Andrew B.,McKenzie, Christine J.,Milligan, Graeme,Ulven, Trond
, p. 3577 - 3595 (2020/04/30)
Free fatty acid receptor 3 (FFA3, previously GPR41) is activated by short-chain fatty acids, mediates health effects of the gut microbiota, and is a therapeutic target for metabolic and inflammatory diseases. The shortage of well-characterized tool compounds has however impeded progress. Herein, we report structure-activity relationship of an allosteric modulator series and characterization of physicochemical and pharmacokinetic properties of selected compounds, including previous and new tools. Two representatives, 57 (TUG-1907) and 63 (TUG-2015), showed improved solubility and preserved potency. Of these, 57, with EC50 = 145 nM and a solubility of 33 μM, showed high clearance in vivo but is a preferred tool in vitro. In contrast, 63, with EC50 = 162 nM and a solubility of 9 μM, showed lower clearance and seems better suited for in vivo studies. Using 57, we demonstrate for the first time that FFA3 activation leads to calcium mobilization in murine dorsal root ganglia.
