18000-24-3 Usage
Description
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL is a quinolinemonocarboxylic acid derivative, specifically quinaldic acid, which is substituted by a hydroxy group at position 4 and a chlorine atom at position 7. 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL exhibits potent antagonistic activity at the strychnine-insensitive glycine site of the NMDA glutamate receptor. It is known for its ability to prevent neurodegeneration caused by quinolinic acid.
Uses
Used in Pharmaceutical Industry:
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL is used as an NMDA receptor antagonist at the glycine site for its neuroprotective properties. It plays a crucial role in the treatment and management of neurodegenerative disorders by modulating the activity of the NMDA receptor, which is implicated in various neurological conditions.
Used in Neuroprotection Research:
In the field of neuroprotection, 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL is utilized as a potent agent to counteract the harmful effects of quinolinic acid, a neurotoxin associated with neurodegeneration. Its ability to prevent neuronal damage makes it a valuable compound in the development of therapeutic strategies for neurodegenerative diseases.
Target
Ki: 0.59 μM (reuptake of glutamate)
?
?IC50: 0.56 μM (Glycine B coagonist site of NMDA receptor)
Biological Functions
Glycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission.
Biological Activity
NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset? .
in vivo
Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.
Check Digit Verification of cas no
The CAS Registry Mumber 18000-24-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,0,0 and 0 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 18000-24:
(7*1)+(6*8)+(5*0)+(4*0)+(3*0)+(2*2)+(1*4)=63
63 % 10 = 3
So 18000-24-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H6ClNO3/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13/h1-4H,(H,12,13)(H,14,15)
18000-24-3Relevant articles and documents
2-AMINOCARBONYL-QUINOLINE COMPOUNDS AS PLATELET ADENOSINE DIPHOSPHATE RECEPTOR ANTAGONISTS
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Page 44, (2010/02/07)
Compounds of formula (I), where m, n, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
