1800044-94-3 Usage
Description
(Z)-N-(1-chloro-1-(furan-2-yl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide, also known as A-121047, is a synthetic benzamide compound with a molecular formula of C22H23ClN2O3 and a molecular weight of 400.88 g/mol. It is characterized by the presence of a benzamide group, a chlorine atom, a furan ring, and a piperidine ring in its chemical structure. A-121047 is a potent and selective dopamine D3 receptor antagonist, which has been investigated for its potential use in the treatment of drug addiction and other neurobehavioral disorders.
Uses
Used in Pharmaceutical Industry:
A-121047 is used as a pharmacological agent for the treatment of drug addiction and other neurobehavioral disorders. Its application is based on its potent and selective antagonistic action on the dopamine D3 receptor, which plays a significant role in various physiological and pathological processes related to addiction and neurobehavioral disorders.
Used in Research and Development:
A-121047 is used as a research tool to understand the role of the dopamine D3 receptor in physiological and pathological processes. Its high affinity for the D3 receptor makes it a valuable compound for studying the receptor's function and potential therapeutic targets for related disorders.
Used in Drug Design and Development:
The unique chemical structure of A-121047, which includes a benzamide group, a chlorine atom, a furan ring, and a piperidine ring, makes it a useful starting point for the design and development of new drugs targeting the dopamine D3 receptor. Its potent and selective antagonistic action can be leveraged to create novel compounds with improved pharmacological properties and therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 1800044-94-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,0,0,0,4 and 4 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1800044-94:
(9*1)+(8*8)+(7*0)+(6*0)+(5*0)+(4*4)+(3*4)+(2*9)+(1*4)=123
123 % 10 = 3
So 1800044-94-3 is a valid CAS Registry Number.
1800044-94-3Relevant articles and documents
Synthesis and quantitative structure-activity relationships study for phenylpropenamide derivatives as inhibitors of hepatitis B virus replication
Yang, Jing,Ma, Min,Wang, Xue-Ding,Jiang, Xing-Jun,Zhang, Yuan-Yuan,Yang, Wei-Qing,Li, Zi-Cheng,Wang, Xi-Hong,Yang, Bin,Ma, Meng-Lin
, p. 82 - 91 (2015/07/27)
A series of new phenylpropenamide derivatives containing different substituents was synthesized, characterized and evaluated for their anti-hepatitis B virus (HBV) activities. The quantitative structure eactivity relationships (QSAR) of phenylpropenamide compound have been studied. The 2D-QSAR models, based on DFT and multiple linear regression analysis methods, revealed that higher values of total energy (TE) and lower entropy (Sθ) enhanced the anti-HBV activities of the phenylpropenamide molecules. Predictive 3D-QSAR models were established using SYBYL multifit molecular alignment rule. The optimum models were all statistically significant with cross-validated and conventional coefficients, indicating that they were reliable enough for activity prediction.
