18002-26-1

Basic information

• Product Name: 1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
• CAS NO: 18002-26-1
• Molecular Formula: C₈H₁₀N₂O₃
• Molecular Weight: 182.1766
• Mol File: 18002-26-1.mol
• Article Data: 5

Chemical Properties

• Density: 1.367g/cm³
• Refractive Index: 1.563
• CAS DataBase Reference: 1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione(18002-26-1)
• EPA Substance Registry System: 1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione(18002-26-1)

Safety Data

• Hazardous Substances Data: 18002-26-1(Hazardous Substances Data)

Usage

General Description

1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione, also known as THF-2-ylpyrimidine-2,4-dione, is a chemical compound with potential use in pharmaceutical research and development. It is a heterocyclic compound with a tetrahydrofuran ring and a pyrimidine ring, and it exists as a white powder. 1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione has been studied for its potential as an anticancer agent and has shown promising results in inhibiting the growth of certain cancer cells. It also has potential applications in the treatment of neurodegenerative diseases and as an antiviral agent. Further research is ongoing to explore the full range of pharmacological properties and potential uses of 1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione.

Upstream product

• 67095-56-1 1,3-bis-tetrahydrofuran-2-yl-1H-pyrimidine-2,4-dione 
• 1608-67-9 2-acetoxytetrahydrofuran 
• 10457-14-4 O,O'-bis-(trimethylsilyl)uracil 
• 66-22-8 uracil 

Downstream Products

• 17902-23-7 tegafur 
• 887246-99-3 3-(2-diethoxyphosphinylbenzyl)-1-(tetrahydrofuran-2-yl)pyrimidine-2,4-dione 
• 890524-70-6 3-(3,5-dimethyl-benzyl)-1-(tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists

N3-Substitution of the uracil ring of willardiine with a variety of carboxyalkyl or carboxybenzyl substituents produces AMPA and kainate receptor antagonists. In an attempt to improve the potency and selectivity of these AMPA and kainate receptor antagonists a series of analogues with different terminal acidic groups and interacidic group spacers was synthesized and pharmacologically characterized. (5′)-1-(2-Amino-2-carboxyethyl)-3-(2- carboxythiophene-3-ylmethyl)pyrimidine-2,4-dione (43, UBP304) demonstrated high potency and selectivity toward native GLUK5-containing kainate receptors (KD 0.105 ± 0.007 μM vs kainate on native GLUK5; KD 71.4 ± 8.3 μM vs (S)-5- fluorowillardiine on native AMPA receptors). On recombinant human GLU K5, GLUK5/GLUK6, and GLUK5/GLU K2, KB values of 0.12 ± 0.03, 0.12 ± 0.01, and 0.18 ± 0.02 μM, respectively, were obtained for 43. However, 43 displayed no activity on homomeric GLUK6 or GLUK7 kainate receptors or homomeric GLUA1-4 AMPA receptors (IC50 values > 100 μM). Thus, 43 is a potent and selective GLUK5 receptor antagonist.

FACILE SYNTHESIS OF TETRAHYDRO-2-FURYLATED PYRIMIDINES AND PURINES USING A NEW CATALYST OF CESIUM CHLORIDE

1-(Tetrahydro-2-furyl)pyrimidine and 9-(tetrahydro-2-furyl)purine derivatives were successfully synthesized in good yields by the reactions of trimethylsilylated pyrimidine and purine bases with 2-acetoxytetrahydrofuran using a new catalyst of cesium chloride in acetonitrile under mild conditions.

Selective N1-tetrahydrofurylation of 5-substituted uracils

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