180136-14-5

Basic information

• Product Name: Cyclohexanepropanamide, N-(3-formyl-4-methylphenyl)-
• CAS NO: 180136-14-5
• Molecular Formula: C17H23NO2
• Molecular Weight: 273.375
• Mol File: 180136-14-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Cyclohexanepropanamide, N-(3-formyl-4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanepropanamide, N-(3-formyl-4-methylphenyl)-(180136-14-5)
• EPA Substance Registry System: Cyclohexanepropanamide, N-(3-formyl-4-methylphenyl)-(180136-14-5)

Safety Data

• Hazardous Substances Data: 180136-14-5(Hazardous Substances Data)

Upstream product

• 111437-10-6 3-(hydroxymethyl)-4-methylaniline 
• 1975-52-6 5-nitro-o-toluic acid 
• 22474-47-1 (2-methyl-5-nitro-7-phenyl)methanol 
• 180136-13-4 3-Cyclohexyl-N-(3-hydroxymethyl-4-methyl-phenyl)-propionamide 

Relevant articles and documents

New low-density lipoprotein receptor upregulators acting via a novel mechanism

The synthesis and biological activity of a new series of benzamides and related compounds that upregulate the expression of the low-density lipoprotein (LDL) receptor in human hepatocytes (HepG2 cells) by a novel mechanism are described. The lead compound, N-[5-[(3- cyclohexylpropionyl)amino]-2-methylphenyl]-4-hydroxybenzamide (1, RPR102359), increased the expression of the LDL receptors in HepG2 cells by 80% when tested at a concentration of 3 μM. Mevinolin (lovastatin) was found to increase the LDL receptor expression by 70% at the same concentration. In contrast to mevinolin, 1 was found to have no effect on cholesterol biosynthesis in liver homogenates or in HepG2 cells at doses where substantial upregulation of the LDL receptor was observed and thus stimulated LDL receptor expression by a novel mechanism.