18015-04-8Relevant articles and documents
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Egorova et al.
, (1967)
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Reaction of 6-aminouracils with aldehydes in water as both solvent and reactant under FeCl3·6H2O catalysis: Towards 5-alkyl/arylidenebarbituric acids
Kalita, Subarna Jyoti,Mecadon, Hormi,Chandra Deka, Dibakar
, p. 32207 - 32213 (2014/08/18)
5-Alkyl/arylidenebarbituric acids were efficiently synthesized through an FeCl3·6H2O catalyzed domino reaction of 6-aminouracils, water and aldehydes with water serving a dual role as both solvent and reactant, under benign reaction conditions. A study on comparative substrate scope of 6-aminouracil versus barbituric acid showed similar efficacy towards 5-alkyl/arylidenebarbituric acids. The protocol is the first detailed report to prepare regioselectively 5-alkyl/arylidenebarbituric acids starting from 6-aminouracils, which is an alternative and competing strategy to hitherto all known reactions directly employing barbituric acids. the Partner Organisations 2014.
Organocatalysis of c?￡/c?￡N and C?￡C/ C?￡N exchange in dynamic covalent chemistry
Wilhelms, Nadine,Kulchat, Sirinan,Lehn, Jean-Marie
, p. 2635 - 2651 (2013/03/13)
The reversibly formed C?￡N bond plays a very important role in dynamic covalent chemistry and the C?￡N/C?￡N exchange of components between different imine constituents to create dynamic covalent libraries has been extensively used. To facilitate diversity generation, we have investigated an organocatalyzed approach, using L-proline as catalyst, to accelerate the formation of dynamic libraries of [n×n] imine components. The organocatalysis methodology has also been extended, under somewhat modified conditions, to reversible C?￡C/C?￡N exchange processes between Knoevenagel derivatives of barbituric acid and imines, allowing for the generation of increased diversity. Copyright
