180185-61-9 Usage
Description
(2R,4S)-(-)-N-[4-(Diethoxyphosphorylmethyl)phenyl]-4-methyl-7,8-(methylenedioxy)-5-oxo-1,2,4,5-tetrahydro-3-benzothiepine-2-carboxamide is a complex organic molecule with a tetrahydrobenzothiepine core structure. It features a carboxamide functional group and a diethoxyphosphorylmethyl substituent attached to a phenyl group. Additionally, the compound has a methylenedioxy group and a methyl group attached to the benzothiepine ring. This unique structure may confer potential biological activities, making it a candidate for pharmaceutical research and development. However, further research and evaluation are required to determine its specific properties and potential uses.
Uses
Used in Pharmaceutical Research and Development:
(2R,4S)-(-)-N-[4-(Diethoxyphosphorylmethyl)phenyl]-4-methyl-7,8-(methylenedioxy)-5-oxo-1,2,4,5-tetrahydro-3-benzothiepine-2-carboxamide is used as a chemical compound for pharmaceutical research and development due to its unique structure and potential biological activities. Its tetrahydrobenzothiepine core, along with the carboxamide functional group and diethoxyphosphorylmethyl substituent, may contribute to its potential as a therapeutic agent or a lead compound for further optimization.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (2R,4S)-(-)-N-[4-(Diethoxyphosphorylmethyl)phenyl]-4-methyl-7,8-(methylenedioxy)-5-oxo-1,2,4,5-tetrahydro-3-benzothiepine-2-carboxamide is used as a starting point for the design and synthesis of new drugs. Its structural features can be modified to explore various biological targets and pathways, potentially leading to the development of novel therapeutic agents.
Used in Drug Discovery:
(2R,4S)-(-)-N-[4-(Diethoxyphosphorylmethyl)phenyl]-4-methyl-7,8-(methylenedioxy)-5-oxo-1,2,4,5-tetrahydro-3-benzothiepine-2-carboxamide is used in drug discovery as a potential lead compound. Its unique structure and potential biological activities make it a promising candidate for further investigation and optimization to develop new drugs with improved efficacy and safety profiles.
Used in Biochemical Research:
In biochemical research, (2R,4S)-(-)-N-[4-(Diethoxyphosphorylmethyl)phenyl]-4-methyl-7,8-(methylenedioxy)-5-oxo-1,2,4,5-tetrahydro-3-benzothiepine-2-carboxamide is used as a tool compound to study the interactions between small molecules and biological targets. Its structural features can provide insights into the binding mechanisms and help in understanding the molecular basis of various diseases and conditions.
Note: The specific applications and industries mentioned above are hypothetical and provided as examples based on the general properties of complex organic molecules with potential biological activities. The actual uses of (2R,4S)-(-)-N-[4-(Diethoxyphosphorylmethyl)phenyl]-4-methyl-7,8-(methylenedioxy)-5-oxo-1,2,4,5-tetrahydro-3-benzothiepine-2-carboxamide would depend on the results of further research and evaluation.
Check Digit Verification of cas no
The CAS Registry Mumber 180185-61-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,0,1,8 and 5 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 180185-61:
(8*1)+(7*8)+(6*0)+(5*1)+(4*8)+(3*5)+(2*6)+(1*1)=129
129 % 10 = 9
So 180185-61-9 is a valid CAS Registry Number.
180185-61-9Relevant articles and documents
Synthesis of novel 2-benzothiopyran and 3-benzothiepin derivatives and their stimulatory effect on bone formation
Oda, Tsuneo,Notoya, Kohei,Gotoh, Masayuki,Taketomi, Shigehisa,Fujisawa, Yukio,Makino, Haruhiko,Sohda, Takashi
, p. 751 - 760 (2007/10/03)
In a search for therapeutic agents for the treatment of osteoporosis and bone fracture, we found that 2-benzothiopyran-1-carboxamide derivatives 1, derived from ipriflavone as a lead compound, increase cellular alkaline phosphatase activity in cultures of rat bone marrow stromal cells. Further modification of 1 has led to the discovery of more potent 3-benzothiepin-2- carboxamide derivatives 2. Of these, 3-benzothiepin derivatives bearing a 4- (dialkoxyphosphorylmethyl)phenyl group on the 2-carboxamide moiety such as 2h and 2q exhibited significant improvement of activity compared to ipriflavone. Asymmetric synthesis of 2h and 2q revealed that the (-)-isomers possessed activities superior to those of the (+)-isomers. Further evaluation of these compounds using the mouse osteoblastic cell line MC3T3-E1 revealed that (-)- 2q enhanced the effect of bone morphogenetic protein. In addition, application of a sustained-release agent containing 2q increased the area of newly formed bone in a rat skull defect model. Based on these findings, (-)- 2q was selected for further investigation as a new drug stimulating bone formation. Synthesis and structure-activity relationships for this novel series of 2-benzothiopyran and 3-benzothiepin derivatives are detailed.
