180285-55-6Relevant articles and documents
Synthetic studies on the azinothricin family of antitumour antibiotics. 5. Asymmetric synthesis of two activated esters for the northern sector of A83586C
Hale, Karl J.,Cai, Jiaqiang
, p. 4233 - 4236 (2007/10/03)
An asymmeric synthesis of the activated esters 20 and 21 is reported. Both molecules equate with the C(28)-C(47) region of A83586C, and contain functionality appropriate for future unification with the hexapeptide unit. A useful new reaction is described for converting a methyl ester directly into a thioethyl or HOBT ester that operates under very mild conditions.